Ekstrand J, Waller R, Forsberg A, Fredholm B
Scand J Dent Res. 1986 Dec;94(6):507-14. doi: 10.1111/j.1600-0722.1986.tb01793.x.
The effect of fluoride ingestion on plasma and urinary cyclic AMP levels was studied in healthy volunteers, children undergoing prophylactic fluoride treatment and in rats. In the first series of experiments fluoride ingestion led to a 20-fold increase in plasma fluoride concentration, which was unrelated to changes in plasma cyclic AMP. The only significant effect on plasma cyclic AMP occurred prior to fluoride, an effect attributed to stress. In the second series performed in children increases in urinary F- of up to 200-fold were associated with slight but nonsignificant changes in cyclic AMP excretion. In rat experiments the blood sampling procedure was associated with a rise in plasma cyclic AMP. When this was prevented by pretreatment with propranolol (3 mg/kg), the effect of fluoride (50 ppm in the drinking water) was tested. A fall in urine production was not associated with any change in cyclic AMP excretion or in nephrogenic cyclic AMP. It is concluded that if fluoride alters cyclic AMP in rats and man the effect is small and easily masked by other factors such as catecholamine release following stress.
在健康志愿者、接受预防性氟化物治疗的儿童以及大鼠中研究了摄入氟化物对血浆和尿中环磷酸腺苷（cAMP）水平的影响。在第一组实验中，摄入氟化物导致血浆氟化物浓度增加了20倍，这与血浆cAMP的变化无关。对血浆cAMP唯一显著的影响发生在摄入氟化物之前，这种影响归因于应激。在对儿童进行的第二组实验中，尿氟增加高达200倍与cAMP排泄的轻微但不显著变化有关。在大鼠实验中，采血过程与血浆cAMP升高有关。当用普萘洛尔（3mg/kg）预处理预防这种情况时，测试了氟化物（饮用水中50ppm）的作用。尿量减少与cAMP排泄或肾源性cAMP的任何变化均无关。得出的结论是，如果氟化物改变大鼠和人类体内的cAMP，其影响很小，并且很容易被其他因素掩盖，例如应激后儿茶酚胺的释放。
