Department of Immunodermatology, St John's Institute of Dermatology, Kings College London, London, UK.
Department of Dermatology, University Hospitals Leicester, Leicester, UK.
Clin Exp Dermatol. 2019 Apr;44(3):290-294. doi: 10.1111/ced.13774. Epub 2018 Oct 2.
Pemphigus foliaceus (PF) has both genetic and environmental susceptibility factors. Current data on human leucocyte antigen (HLA) in patients with sporadic PF are limited.
To better define the distribution of HLA alleles in patients with PF in the UK.
We recruited 36 patients [26 of white British (WB) descent, 10 of Indo-Asian (IA) descent] with PF who were living in the UK and 159 ethnically matched normal controls, and analysed their class II HLA DRB1 and DQB1 allele distribution.
There was an increased frequency of DRB11404 in association with DQB10503 in IA patients with PF. The DRB104 allele group as a whole had an increased frequency (P < 0.001) in the WB patient group compared with controls. The alleles contributing to this significance were DRB10401 (P = 0.03) and DRB1*0404 (P < 0.01).
This is the largest HLA association study in sporadic PF from the UK to date. There appears to be a difference in PF susceptibility alleles between WB and IA patients, highlighting the importance of racial variation in genetic susceptibility to disease development.
落叶型天疱疮（PF）既有遗传易感性因素，也有环境易感性因素。目前有关散发性 PF 患者人类白细胞抗原（HLA）的数据有限。
更好地确定英国 PF 患者中 HLA 等位基因的分布。
我们招募了 36 名居住在英国的 PF 患者（26 名白种英国人（WB），10 名印度-亚洲人（IA））和 159 名种族匹配的正常对照者，并分析了他们的 II 类 HLA-DRB1 和 DQB1 等位基因分布。
IA 型 PF 患者中 DRB11404 与 DQB10503 相关的频率增加。与对照组相比，WB 患者组整个 DRB104 等位基因组的频率增加（P < 0.001）。导致这种显著差异的等位基因是 DRB10401（P = 0.03）和 DRB1*0404（P < 0.01）。
这是迄今为止英国最大的散发性 PF 的 HLA 关联研究。WB 和 IA 患者之间似乎存在 PF 易感性等位基因的差异，这突出了疾病发展中遗传易感性的种族差异的重要性。
