[ROLE OF C-REACTIVE PROTEIN AND TUMOR NECROSIS FACTOR-α IN IMMUNOREGULATION SYSTEM IN PATIENTS WITH CONCOMITANT COURSE OF CHRONIC PANCREATITIS AND TYPE 2 DIABETES MELLITUS].

PURPOSE

To determine the content of markers of inflammation, namely C-reactive protein and tumor necrosis factor-α in patients with combined course of chronic pancreatitis and type 2 diabetes mellitus.

MATERIALS AND METHODS

The investigation involved of 20 patients with isolated chronic pancreatitis and 20 patients with combined course of chronic pancreatitis and type 2 diabetes mellitus. The control group consisted of 20 healthy individuals.

RESULTS

It was found that patients with combined course of chronic pancreatitis and type 2 diabetes had significantly higher levels of C-reactive protein and hyper-TNF-α-emia (p < 0.05). Patients of all study groups revealed a close correlation between C-reactive protein and tumor necrosis factor-α (p < 0.05)/

CONCLUSIONS

The results of the study suggest that the levels of C-reactive protein and tumor necrosis factor-α are important diagnostic markers of inflammation in patients with chronic pancreatitis and type 2 diabetes mellitus.