Jakschik B A, Wei Y F, Rengers T A
Adv Prostaglandin Thromboxane Leukot Res. 1986;16:141-52.
The experiments discussed above demonstrate that macrophages and possibly PMN modulate and contribute to immediate hypersensitivity reactions. Antigen stimulation of sensitized mast cells in vitro in the presence of macrophages showed that the latter contribute prostaglandins and modulate the 5-lipoxygenase products. Early in the time course, 5-lipoxygenase products, including leukotrienes, were enhanced and later decreased. The decrease appeared to be due to active oxygen species and may serve as a negative feedback mechanism to maintain relative homeostasis.
上述实验表明，巨噬细胞以及可能还有中性粒细胞可调节并促成速发型超敏反应。在巨噬细胞存在的情况下，体外对抗原致敏的肥大细胞进行刺激，结果显示巨噬细胞会产生前列腺素并调节5-脂氧合酶产物。在时间进程的早期，包括白三烯在内的5-脂氧合酶产物会增加，随后减少。这种减少似乎是由于活性氧物质导致的，可能作为一种负反馈机制来维持相对的内稳态。
