Department of Nephrology & Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
Department of Nephrology, Free University Amsterdam, Amsterdam, The Netherlands.
Nephrol Dial Transplant. 2018 Oct 1;33(suppl_3):iii53-iii58. doi: 10.1093/ndt/gfy218.
Haemodiafiltration (HDF) combines diffusive and convective solute removal in a single treatment session. HDF provides a greater removal of higher molecular weight uraemic retention solutes than conventional high-flux haemodialysis (HD). Recently completed randomized clinical trials suggest better patient survival with online HDF. The treatment is mainly used in Europe and Japan. This review gives a brief overview of the presently available evidence of the effects of HDF on clinical end points, it speculates on possible mechanisms of a beneficial effect of HDF as compared with standard HD and ends with some perspectives for the future.
血液透析滤过（HDF）在单次治疗中结合了弥散和对流两种溶质清除方式。与传统高通量血液透析（HD）相比，HDF 能更有效地清除高分子量尿毒症潴留溶质。最近完成的随机临床试验表明，在线 HDF 治疗可提高患者生存率。该治疗方法主要在欧洲和日本使用。本文简要综述了 HDF 对临床终点的影响的现有证据，推测了 HDF 与标准 HD 相比可能具有有益效果的机制，并对未来的前景进行了展望。
