色素细胞与黑色素瘤研究前沿。
Frontiers in pigment cell and melanoma research.
机构信息
Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, Merced, California.
Department of Dermatology, University of Colorado Denver, Aurora, Colorado.
出版信息
Pigment Cell Melanoma Res. 2018 Nov;31(6):728-735. doi: 10.1111/pcmr.12728. Epub 2018 Oct 3.
In this perspective, we identify emerging frontiers in clinical and basic research of melanocyte biology and its associated biomedical disciplines. We describe challenges and opportunities in clinical and basic research of normal and diseased melanocytes that impact current approaches to research in melanoma and the dermatological sciences. We focus on four themes: (1) clinical melanoma research, (2) basic melanoma research, (3) clinical dermatology, and (4) basic pigment cell research, with the goal of outlining current highlights, challenges, and frontiers associated with pigmentation and melanocyte biology. Significantly, this document encapsulates important advances in melanocyte and melanoma research including emerging frontiers in melanoma immunotherapy, medical and surgical oncology, dermatology, vitiligo, albinism, genomics and systems biology, epidemiology, pigment biophysics and chemistry, and evolution.
在这篇观点文章中，我们确定了黑素细胞生物学及其相关生物医学学科的临床和基础研究中的新兴前沿。我们描述了正常和患病黑素细胞的临床和基础研究中的挑战和机遇，这些挑战和机遇影响了目前对黑色素瘤和皮肤科学研究的方法。我们专注于四个主题：（1）临床黑色素瘤研究，（2）基础黑色素瘤研究，（3）临床皮肤科，（4）基础色素细胞研究，旨在概述与色素沉着和黑素细胞生物学相关的当前重点、挑战和前沿。重要的是，本文涵盖了黑素细胞和黑色素瘤研究的重要进展，包括黑色素瘤免疫治疗、医学和外科肿瘤学、皮肤科、白癜风、白化病、基因组学和系统生物学、流行病学、色素生物物理学和化学以及进化方面的新兴前沿。
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