Amandus H E, Althouse R, Morgan W K, Sargent E N, Jones R
Am J Ind Med. 1987;11(1):27-37. doi: 10.1002/ajim.4700110104.
A study was conducted to estimate the exposure-response relationship for tremolite-actinolite fiber exposure and radiographic findings among 184 men employed at a Montana vermiculite mine and mill. Workers were included if they had been employed during 1975-1982 and had achieved at least 5 years tenure at the Montana site. Past fiber exposure was associated with an increased prevalence of parenchymal and pleural radiographic abnormalities. Smoking was not significantly related to the prevalence of small opacities. However, the number of workers who had never smoked was small, and this prevented measurement of the smoking effect. Under control for smoking and age, the prevalence of small opacities was significantly greater for vermiculite workers with greater than 100 fiber/cc-years exposure than for comparison groups (cement workers, blue collar workers, and coal miners) who had no known occupational fiber exposure. A logistic model predicted an increase of 1.3% in the odds ratio for small opacities at an additional exposure of 5 fiber-years.
一项研究旨在评估蒙大拿州蛭石矿和加工厂的184名男性工人中，透闪石-阳起石纤维暴露与影像学表现之间的暴露-反应关系。纳入的工人需在1975年至1982年期间受雇，且在蒙大拿州工作至少5年。既往纤维暴露与实质和胸膜影像学异常的患病率增加有关。吸烟与小阴影的患病率无显著关联。然而，从不吸烟的工人数量较少，这使得无法测量吸烟的影响。在控制吸烟和年龄因素后，蛭石工人中纤维暴露超过100纤维/立方厘米-年的小阴影患病率显著高于无已知职业性纤维暴露的对照组（水泥工人、蓝领工人和煤矿工人）。逻辑模型预测，额外暴露5纤维-年，小阴影的优势比将增加1.3%。
