Tobey J C, Weaver L C
Am J Physiol. 1987 Jan;252(1 Pt 2):R26-33. doi: 10.1152/ajpregu.1987.252.1.R26.
Influences of sinoaortic and vagally innervated vascular pressoreceptors on excitatory splenic and renal sympathetic responses to splenic receptor stimulation were investigated in anesthetized cats. These experiments demonstrated that these pressoreceptors have little apparent effect on the magnitude of splenic nerve responses to splenic receptor stimulation by capsaicin, bradykinin, or congestion. In contrast, activation of these pressoreceptors attenuated renal nerve responses to splenic receptor stimulation. Influences of sinoaortic and vagally innervated receptors on tonic sympathetic nerve activity also were evaluated. Stimulation of these receptors by small increases in arterial pressure (15-21 mmHg) caused equivalent inhibition of splenic and renal nerve activity; large increases (50-66 mmHg) caused significantly greater inhibition of renal than splenic nerve activity. These results illustrate that excitatory renal and splenic sympathetic responses to splenic receptor stimulation are not suppressed equally by pressoreceptor activation, vascular pressoreceptors can have greater inhibitory influences on tonic renal than splenic nerve activity, and vascular pressoreceptor influences on sympathetic reflexes are similar to those on tonic nerve activity.
在麻醉猫身上研究了窦主动脉和迷走神经支配的血管压力感受器对脾和肾交感神经对脾感受器刺激的兴奋性反应的影响。这些实验表明，这些压力感受器对辣椒素、缓激肽或充血引起的脾神经对脾感受器刺激的反应幅度几乎没有明显影响。相反，这些压力感受器的激活减弱了肾神经对脾感受器刺激的反应。还评估了窦主动脉和迷走神经支配的感受器对紧张性交感神经活动的影响。动脉压小幅升高（15 - 21 mmHg）刺激这些感受器会对脾和肾神经活动产生同等程度的抑制；大幅升高（50 - 66 mmHg）则对肾神经活动的抑制明显大于对脾神经活动的抑制。这些结果表明，压力感受器激活对脾感受器刺激引起的肾和脾交感神经兴奋性反应的抑制作用并不相同，血管压力感受器对紧张性肾神经活动的抑制作用比对脾神经活动的抑制作用更大，并且血管压力感受器对交感反射的影响与对紧张性神经活动的影响相似。
