Roche Eric, Clarke Mary, Browne Stephen, Turner Niall, McTuige Orflaith, Kamali Moaayad, Kinsellla Anthony, Larkin Conall, Waddington John L, O'Callaghan Eadbhard
Early Intervention in Psychosis Service,Block 5,Blackrock Business Park,Carysfort Avenue,Blackrock,Co Dublin,Ireland.
Stanley Research Unit,Dept of Adult Psychiatry,St. John of God Hospitaller Services,Dublin,Ireland and Dept of Psychiatry,School of Medicine,University College Dublin,Ireland.
Ir J Psychol Med. 2010 Mar;27(1):15-18. doi: 10.1017/S0790966700000860.
Reported rates of depression in schizophrenia vary considerably.
To measure the prevalence of depression in a first episode sample of people with schizophrenia.
All referrals with a first episode of schizophrenia diagnosed using SCID interviews were assessed pre-discharge and again six months later. We used the Calgary Depression Scale for Schizophrenia (CDSS) and Positive and Negative Syndrome Scale (PANSS) to assess the severity of symptoms.
Pre-discharge, 10.4% of the sample met CDSS criteria for depression. According to the PANSS depression (PANSS -D) subscale, 3% of patients were depressed, with a mean score of 7.48 (SD = 2.97). Only 3% of patients pre-discharge were found to be depressed on both the CDSS and the PANSS-D. Six months later 6.5% were depressed according to the CDSS. However none reached depression criteria according to the PANSS-D. The CDSS correlated with PANSS-D both pre-discharge and at follow-up. Feelings of depression and self-deprecation were the most common symptoms at baseline and follow-up. The CDSS was unrelated to negative symptoms at both stages. A lifetime history of alcohol abuse increased the risk for depression.
Rates of depression in this sample were low. The CDSS appears to discriminate between depression and negative symptoms. Like the general population, alcohol misuse is a risk factor for depression in first episode schizophrenia.
精神分裂症患者中抑郁症的报告发病率差异很大。
测量精神分裂症首发患者样本中抑郁症的患病率。
所有通过SCID访谈诊断为精神分裂症首发的转诊患者在出院前及六个月后再次接受评估。我们使用卡尔加里精神分裂症抑郁量表（CDSS）和阳性与阴性症状量表（PANSS）来评估症状的严重程度。
出院前，10.4%的样本符合CDSS抑郁症标准。根据PANSS抑郁（PANSS -D）分量表，3%的患者有抑郁症状，平均得分为7.48（标准差 = 2.97）。出院前只有3%的患者在CDSS和PANSS -D上均被发现有抑郁症状。六个月后，根据CDSS，6.5%的患者有抑郁症状。然而，根据PANSS -D，无人达到抑郁标准。CDSS在出院前和随访时均与PANSS -D相关。抑郁情绪和自我贬低是基线和随访时最常见的症状。在两个阶段，CDSS均与阴性症状无关。有酒精滥用的终生史会增加患抑郁症的风险。
该样本中抑郁症的发病率较低。CDSS似乎能够区分抑郁症状和阴性症状。与普通人群一样，酒精滥用是首发精神分裂症患者患抑郁症的一个风险因素。
