胎儿脑部感染并非巴西寨卡病毒的特有特征。
Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses.
机构信息
Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia 4072, Australia.
Inflammation Biology Group, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.
出版信息
Viruses. 2018 Oct 3;10(10):541. doi: 10.3390/v10100541.
The recent emergence of Zika virus (ZIKV) in Brazil was associated with an increased number of fetal brain infections that resulted in a spectrum of congenital neurological complications known as congenital Zika syndrome (CZS). Herein, we generated from sequence data an early Asian lineage ZIKV isolate (ZIKV-MY; Malaysia, 1966) not associated with microcephaly and compared the replication kinetics and fetal brain infection in interferon α/β receptor 1 knockout (IFNAR1) dams of this isolate and of a Brazilian isolate (ZIKV-Natal; Natal, 2015) unequivocally associated with microcephaly. The replication efficiencies of ZIKV-MY and ZIKV-Natal in A549 and Vero cells were similar, while ZIKV-MY replicated more efficiently in wild-type (WT) and IFNAR mouse embryonic fibroblasts. Viremias in IFNAR1 dams were similar after infection with ZIKV-MY or ZIKV-Natal, and importantly, infection of fetal brains was also not significantly different. Thus, fetal brain infection does not appear to be a unique feature of Brazilian ZIKV isolates.
最近在巴西出现的寨卡病毒（ZIKV）与大量胎儿脑部感染有关，导致了一系列被称为先天性寨卡综合征（CZS）的先天性神经并发症。在此，我们从序列数据中生成了一种与小头畸形无关的早期亚洲谱系寨卡病毒分离株（ZIKV-MY；马来西亚，1966 年），并比较了该分离株和巴西分离株（ZIKV-Natal；巴西，2015 年）在干扰素 α/β 受体 1 敲除（IFNAR1）母鼠中的复制动力学和胎儿脑部感染情况。ZIKV-MY 和 ZIKV-Natal 在 A549 和 Vero 细胞中的复制效率相似，而 ZIKV-MY 在野生型（WT）和 IFNAR 小鼠胚胎成纤维细胞中的复制效率更高。感染 ZIKV-MY 或 ZIKV-Natal 后，IFNAR1 母鼠中的病毒血症相似，重要的是，胎儿脑部感染也没有明显差异。因此，胎儿脑部感染似乎不是巴西寨卡病毒分离株的独特特征。
Zotero 插件