Asadpour Abdoreza, Jahed Mehran, Mahmoudian Saeid
Department of Electrical Engineering, Sharif University of Technology, Tehran, Iran.
ENT and Head & Neck Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Front Integr Neurosci. 2018 Sep 19;12:38. doi: 10.3389/fnint.2018.00038. eCollection 2018.
Management and treatment of subjective tinnitus is an ongoing focus of research activities. One of the most viable assessments of such treatment is the evaluation of brain activity in addition to patient response and clinical assessment. This study focuses on sound therapy and evaluation of patients' electroencephalogram (EEG) in order to verify the potency of this approach. Broadband sound therapy was applied to nineteen participants aging from 25 to 64 and suffering from chronic subjective tinnitus to study the difference of brain activity, a) before fake treatment, b) after fake treatment and c) after the main treatment, using EEG and Visual Analog Scale (VAS) for evaluating Residual Inhibition (RI). Four features were extracted using 4-level wavelet decomposition with Symlet 8 as its mother wavelet. For the "After the main treatment" stage, the mean value of wavelet coefficients for the last wavelet level, which corresponded to delta band of EEG, was lower in the FC3 channel based on Two-Sample -Test with significance level of 0.01, as compared to the same channel of the "before the treatment" stage, for cases in which decreased tinnitus loudness were reported.
主观性耳鸣的管理与治疗一直是研究活动的重点。对这种治疗最可行的评估之一，除了患者反应和临床评估外，还包括对大脑活动的评估。本研究聚焦于声音疗法及对患者脑电图（EEG）的评估，以验证该方法的有效性。对19名年龄在25至64岁之间、患有慢性主观性耳鸣的参与者应用宽带声音疗法，使用脑电图和视觉模拟量表（VAS）来评估残余抑制（RI），研究大脑活动在以下三个阶段的差异：a）假治疗前；b）假治疗后；c）主要治疗后。使用以Symlet 8为母小波的4级小波分解提取四个特征。对于“主要治疗后”阶段，在报告耳鸣响度降低的病例中，基于显著性水平为0.01的双样本检验，与“治疗前”阶段同一通道相比，对应于脑电图δ频段的最后一个小波级的小波系数平均值在FC3通道中更低。
