Velho Vernon L, Bhide Anuj Arun, Ansari Sameer A H
Departments of Neurosurgery and Pathology, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, Maharashtra, India.
Asian J Neurosurg. 2018 Jul-Sep;13(3):766-768. doi: 10.4103/ajns.AJNS_11_18.
Mannitol has been used intravenously for decreasing cerebral edema since decades. The study was performed to evaluate the effect of its irrigation on edema in live rats. Edema was induced by artificial brain injury. We hereby present our results on the same using live rats and confirm its beneficial effect on reducing edema when used as irrigation.
The aim of this study is to evaluate the effect of mannitol irrigation in reducing cerebral edema in rat brain after induction of artificial trauma and to compare the results with standard normal saline irrigation using randomized controlled study.
This study was a prospective randomized controlled trial.
A total of 20 fully grown Albino Wistar rats were subjected to artificial trauma after a burr hole and divided randomly into two groups of ten rats each. One group was subjected to mannitol irrigation after durotomy and the other was subjected to normal saline. Tissue biopsy was sent at the end of 1 h to check for the status of edema and was classified into three grades.
Comparison of proportions test.
Mannitol irrigation produced a statistically significant difference ( = 0.022) in the grade of edema at the end of 1 h as compared to normal saline.
Mannitol irrigation can be used during neurosurgical procedures instead of normal saline to reduce postoperative brain edema.
几十年来，甘露醇一直被静脉注射用于减轻脑水肿。本研究旨在评估其冲洗对活体大鼠脑水肿的影响。脑水肿由人工脑损伤诱导产生。在此，我们展示使用活体大鼠的相关结果，并证实其作为冲洗液使用时对减轻水肿具有有益作用。
本研究的目的是评估甘露醇冲洗对人工创伤诱导的大鼠脑水肿减轻的效果，并通过随机对照研究将结果与标准生理盐水冲洗进行比较。
本研究为前瞻性随机对照试验。
总共20只成年白化Wistar大鼠在钻孔后接受人工创伤，并随机分为两组，每组10只大鼠。一组在硬脑膜切开术后接受甘露醇冲洗，另一组接受生理盐水冲洗。1小时结束时送检组织活检以检查水肿状态，并分为三个等级。
比例检验比较。
与生理盐水相比，甘露醇冲洗在1小时结束时的水肿等级上产生了具有统计学意义的差异（P = 0.022）。
在神经外科手术过程中，可使用甘露醇冲洗而非生理盐水来减轻术后脑水肿。
