Laboratory for the Applied Research on Cardiovascular System, Department of Heart Diseases, Wroclaw Medical University, Wrocław, Poland.
Department of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Heart Fail Rev. 2019 Mar;24(2):269-277. doi: 10.1007/s10741-018-9738-4.
Iron deficiency (ID) is a common and ominous comorbidity in heart failure (HF) and predicts worse outcomes, independently of the presence of anaemia. Accumulated data from animal models of systemic ID suggest that ID is associated with several functional and structural abnormalities of the heart. However, the exact role of myocardial iron deficiency irrespective of systemic ID and/or anaemia has been elusive. Recently, several transgenic models of cardiac-specific ID have been developed to investigate the influence of ID on cardiac tissue. In this review, we discuss structural and functional cardiac consequences of ID in these models and summarize data from clinical studies. Moreover, the beneficial effects of intravenous iron supplementation are specified.
缺铁（ID）是心力衰竭（HF）中一种常见且严重的合并症，并且可预测更差的结局，而与贫血的存在无关。来自系统性 ID 动物模型的累积数据表明，ID 与心脏的几种功能和结构异常有关。然而，心肌缺铁的确切作用（与系统性 ID 和/或贫血无关）一直难以捉摸。最近，已经开发了几种心脏特异性 ID 的转基因模型来研究 ID 对心脏组织的影响。在这篇综述中，我们讨论了这些模型中 ID 对心脏结构和功能的影响，并总结了临床研究的数据。此外，还具体说明了静脉铁补充的有益效果。
