Wang Zengyi, Qi Yue, Liang Xida, Yu Yanping, Chen Jinqiu, Wang Jing, Liu Xinxin, Liu Wu
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.
Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
Int Ophthalmol. 2019 Sep;39(9):1987-1994. doi: 10.1007/s10792-018-1032-x. Epub 2018 Oct 3.
To explore a measuring method for retinal sensitivity in macular hole area by Microperimeter-3 (MP-3) and evaluate its predictive value on visual prognosis.
This was a case series study including 44 eyes of 44 patients with idiopathic macular hole. Retinal sensitivity inside and 0.5 degree outside the macular hole margin was measured, and its mean value was defined as macular hole sensitivity (MHS). Best-corrected visual acuity (BCVA), minimum diameter of macular hole (MD), IS/OS defect diameter, retinal sensitivity in 8 degrees and 2 degrees were also recorded preoperatively and 4 months after operation.
All macular holes were closed after surgery. BCVA was significantly improved from 1.06 ± 0.39 at baseline to 0.31 ± 0.24 at 4 months postoperatively (P < 0.001). Meanwhile, MHS was also significantly improved from 12.02 ± 3.74 dB at baseline to 20.72 ± 4.00 dB at 4 months postoperatively (P < 0.001). MD, preoperative IS/OS defect diameter, preoperative BCVA, preoperative retinal sensitivity in 8 degrees and 2 degrees, and preoperative MHS were all correlated with postoperative BCVA at 4 months, but only preoperative MHS showed liner relationships to postoperative BCVA at 4 months by multivariate stepwise linear analysis.
Macular hole sensitivity by MP-3 could reflect the change of central retinal function after successful macular hole surgery. Compared to preoperative retinal sensitivity in 8 degrees and 2 degrees, preoperative macular hole sensitivity is a better predictor for visual prognosis.
探讨采用微视野计-3（MP-3）测量黄斑裂孔区域视网膜敏感度的方法，并评估其对视觉预后的预测价值。
这是一项病例系列研究，纳入44例特发性黄斑裂孔患者的44只眼。测量黄斑裂孔边缘内及边缘外0.5度处的视网膜敏感度，其平均值定义为黄斑裂孔敏感度（MHS）。术前及术后4个月还记录最佳矫正视力（BCVA）、黄斑裂孔最小直径（MD）、IS/OS缺损直径、8度和2度处的视网膜敏感度。
术后所有黄斑裂孔均闭合。BCVA从基线时的1.06±0.39显著提高至术后4个月时的0.31±0.24（P<0.001）。同时，MHS也从基线时的12.02±3.74dB显著提高至术后4个月时的20.72±4.00dB（P<0.001）。MD、术前IS/OS缺损直径、术前BCVA、术前8度和2度处的视网膜敏感度以及术前MHS均与术后4个月时的BCVA相关，但多因素逐步线性分析显示，仅术前MHS与术后4个月时的BCVA呈线性关系。
MP-3测量的黄斑裂孔敏感度可反映黄斑裂孔手术成功后中心视网膜功能的变化。与术前8度和2度处的视网膜敏感度相比，术前黄斑裂孔敏感度对视觉预后的预测更佳。
