Belosludtsev Iu Iu, Miagkova G I, Evstigneeva R P, Bobrova N I, Pivnitskiĭ K K
Bioorg Khim. 1986 Dec;12(12):1693-5.
Rac-leukotriene A4 methyl ester has been synthesized from propargylic alcohol and 1-heptyne. The synthetic strategy involves the assembly of carbon chain by acetylenide anion condensations and the introduction of (Z)-double bonds by the triple bond hydrogenation.
Rac-白三烯A4甲酯已由炔丙醇和1-庚炔合成。合成策略包括通过乙炔阴离子缩合组装碳链以及通过三键氢化引入(Z)-双键。
