Alcohol Alcohol. 1986;21(4):363-7.
Zinc, copper and lead are known as inhibitory trace metals against brain (Na+-K+)-ATPase. Alcohol (4 g/kg intraperitoneally for 10 days, to rats) induced an elevated level of lead in the cerebral cortex and cerebellum, whereas that of zinc was elevated only in latter region. Copper levels were found to be decreased in the hippocampus, amygdala and hypothalamus, but increased in the spinal cord. Zinc and lead contents were decreased in the amygdala and hypothalamus. The activity of (Na+-K+)-ATPase was enhanced in the hippocampus, amygdala and hypothalamus, but inhibited in the cerebral cortex and cerebellum. It is suggested that alcohol acts differentially on brain zinc, copper and lead concentrations and (Na+-K+)-ATPase activity.
锌、铜和铅被认为是对大脑（钠钾）-ATP酶有抑制作用的痕量金属。给大鼠腹腔注射酒精（4克/千克，持续10天）会导致大脑皮层和小脑中铅含量升高，而锌含量仅在后一个区域升高。发现海马体、杏仁核和下丘脑的铜含量降低，但脊髓中的铜含量增加。杏仁核和下丘脑的锌和铅含量降低。（钠钾）-ATP酶的活性在海马体、杏仁核和下丘脑中增强，但在大脑皮层和小脑中受到抑制。这表明酒精对大脑中锌、铜和铅的浓度以及（钠钾）-ATP酶的活性有不同的作用。
