子宫颈肿瘤中的胎盘型碱性磷酸酶
Placental-type alkaline phosphatase in cervical neoplasia.
作者信息
McLaughlin P J, Warne P H, Hutchinson G E, Johnson P M, Tucker D F
出版信息
Br J Cancer. 1987 Feb;55(2):197-201. doi: 10.1038/bjc.1987.37.
Monoclonal antibodies reactive with placental-type alkaline phosphatase have formed the basis of methods for detection of this oncodevelopmental antigen in patients with pre-invasive and invasive cervical neoplasia, with or without evidence of papilloma virus infection. Disease-related elevations of placental-type alkaline phosphatase were not observed in patients' sera. Solubilised cervical smears or biopsy material, and cervical mucus swabs, often contained substantial amounts of this isoenzyme; however, there was no significant difference between any of the patient and control groups. Thus, serological and smear test assays for placental-type alkaline phosphatase were not useful in differential diagnosis of cervical lesions. However, its presence in most biopsy specimens, often at high levels, indicated possible application for in vivo radioimmunoimaging studies of invasive or metastatic cervical cancer.
与胎盘型碱性磷酸酶发生反应的单克隆抗体，构成了检测早期浸润性和浸润性宫颈癌患者（无论有无乳头瘤病毒感染证据）这一肿瘤发育抗原方法的基础。在患者血清中未观察到与疾病相关的胎盘型碱性磷酸酶升高。溶解的宫颈涂片或活检材料以及宫颈黏液拭子，通常含有大量这种同工酶；然而，任何患者组与对照组之间均无显著差异。因此，胎盘型碱性磷酸酶的血清学和涂片检测方法对宫颈病变的鉴别诊断并无用处。然而，其在大多数活检标本中存在，且常常含量很高，这表明它可能用于浸润性或转移性宫颈癌的体内放射免疫成像研究。
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