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吸烟者血清中胎盘型碱性磷酸酶

Serum placental type alkaline phosphatase in cigarette smokers.

作者信息

McLaughlin P J, Twist A M, Evans C C, Johnson P M

出版信息

J Clin Pathol. 1984 Jul;37(7):826-8. doi: 10.1136/jcp.37.7.826.

DOI:10.1136/jcp.37.7.826
PMID:6378980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC498819/
Abstract

By means of enzyme immunoassays based on two monoclonal antibodies with specificities for distinct forms of placental type alkaline phosphatase (Pl-ALP), together with L-leucine inhibition studies, it has been possible to distinguish the Nagao type carcinoplacental enzyme from other placental type alkaline phosphatases. This approach has shown that it is the Nagao type (placental like) enzyme which is detectable in small amounts in the plasma of healthy individuals, particularly cigarette smokers.

摘要

借助基于两种对不同形式胎盘型碱性磷酸酶（Pl-ALP）具有特异性的单克隆抗体的酶免疫测定法，以及L-亮氨酸抑制研究，已能够将长野型癌胎盘酶与其他胎盘型碱性磷酸酶区分开来。这种方法表明，正是长野型（胎盘样）酶在健康个体的血浆中，尤其是吸烟者的血浆中能够少量检测到。

相似文献

1
Serum placental type alkaline phosphatase in cigarette smokers.吸烟者血清中胎盘型碱性磷酸酶
J Clin Pathol. 1984 Jul;37(7):826-8. doi: 10.1136/jcp.37.7.826.
2
Tissue origin of serum placental-like alkaline phosphatase in cigarette smokers.
Clin Chim Acta. 1986 Mar 28;155(3):329-33. doi: 10.1016/0009-8981(86)90252-4.
3
Placental-type alkaline phosphatase in pregnancy and malignancy plasma: specific estimation using a monoclonal antibody in a solid phase enzyme immunoassay.孕期及恶性肿瘤患者血浆中的胎盘型碱性磷酸酶：在固相酶免疫测定中使用单克隆抗体进行特异性评估。
Clin Chim Acta. 1983 May 30;130(2):199-209. doi: 10.1016/0009-8981(83)90117-1.
4
Analysis of serum placental alkaline phosphatase activity in testicular cancer and cigarette smokers.睾丸癌患者及吸烟者血清胎盘碱性磷酸酶活性分析
Urol Res. 1990;18(3):169-73. doi: 10.1007/BF00295842.
5
Diagnostic aspects of alkaline phosphatase and its isoenzymes.碱性磷酸酶及其同工酶的诊断意义
Clin Biochem. 1987 Aug;20(4):225-30. doi: 10.1016/s0009-9120(87)80002-4.
6
Placental-like alkaline phosphatase in cancer patients determined by enzyme immunoassay (EIA) using monoclonal antibodies.采用单克隆抗体通过酶免疫测定法（EIA）测定癌症患者体内的胎盘样碱性磷酸酶。
Clin Chim Acta. 1989 Aug 15;183(2):239-40. doi: 10.1016/0009-8981(89)90339-2.
7
Demonstration of placental and placental-like alkaline phosphatase in non-malignant human tissue extracts using monoclonal antibodies in an enzyme immunoassay.在酶免疫测定中使用单克隆抗体在非恶性人类组织提取物中检测胎盘和胎盘样碱性磷酸酶。
Clin Chim Acta. 1984 Mar 13;137(3):341-8. doi: 10.1016/0009-8981(84)90122-0.
8
Enzyme immunoassay of human placental and germ-cell alkaline phosphatase in serum.血清中人胎盘碱性磷酸酶和生殖细胞碱性磷酸酶的酶免疫测定
Clin Chem. 1990 Oct;36(10):1793-9.
9
Placental serum alkaline phosphatase, defined by monoclonal antibody C2, in non-malignant diseases and in non-germinal tumors.由单克隆抗体C2定义的胎盘血清碱性磷酸酶在非恶性疾病和非生殖细胞肿瘤中的情况。
Int J Biol Markers. 1993 Oct-Dec;8(4):246-8. doi: 10.1177/172460089300800409.
10
Increased serum placental-like alkaline phosphatase activity in smokers originates from the lungs.吸烟者血清中胎盘样碱性磷酸酶活性增加源于肺部。
Eur J Respir Dis. 1987 Sep;71(3):170-6.

引用本文的文献

1
Serum placental-type alkaline phosphatase activity in women with squamous and glandular malignancies of the reproductive tract.患有生殖道鳞状和腺性恶性肿瘤女性的血清胎盘型碱性磷酸酶活性
J Clin Pathol. 1994 Nov;47(11):1035-7. doi: 10.1136/jcp.47.11.1035.
2
Detection of placental-type alkaline phosphatase in ovarian cancer.卵巢癌中胎盘型碱性磷酸酶的检测
Br J Cancer. 1985 Jul;52(1):59-64. doi: 10.1038/bjc.1985.149.
3
Placental-type alkaline phosphatase in cervical neoplasia.子宫颈肿瘤中的胎盘型碱性磷酸酶
Br J Cancer. 1987 Feb;55(2):197-201. doi: 10.1038/bjc.1987.37.
4
Analysis of serum placental alkaline phosphatase activity in testicular cancer and cigarette smokers.睾丸癌患者及吸烟者血清胎盘碱性磷酸酶活性分析
Urol Res. 1990;18(3):169-73. doi: 10.1007/BF00295842.
5
Placental-like alkaline phosphatase in seminoma.精原细胞瘤中的胎盘样碱性磷酸酶
Urol Res. 1990;18(2):87-92. doi: 10.1007/BF00302465.

本文引用的文献

1
Immunochemical studies of human placental-type variants of alkaline phosphatase. Structural differences between the "Nagao isoenzyme" and the placental "D-variant".人胎盘型碱性磷酸酶变体的免疫化学研究。“长尾同工酶”与胎盘“D变体”之间的结构差异。
Eur J Biochem. 1981 Aug;118(1):39-45. doi: 10.1111/j.1432-1033.1981.tb05483.x.
2
A possible new locus of alkaline phosphatase expressed in human testis.人睾丸中表达的碱性磷酸酶的一个可能新位点。
Hum Genet. 1982;62(4):293-5. doi: 10.1007/BF00304541.
3
Expression on cultured human tumour cells of placental trophoblast membrane antigens and placental alkaline phosphatase defined by monoclonal antibodies.由单克隆抗体界定的胎盘滋养层膜抗原和胎盘碱性磷酸酶在培养的人肿瘤细胞上的表达。
Int J Cancer. 1982 Jul 15;30(1):21-6. doi: 10.1002/ijc.2910300105.
4
Characterization and use of an allotype-specific monoclonal antibody to placental alkaline phosphatase in the study of cancer-related phosphatase polymorphism.在癌症相关磷酸酶多态性研究中对胎盘碱性磷酸酶同种异型特异性单克隆抗体的表征及应用。
Cancer Res. 1982 Jun;42(6):2444-9.
5
Sensitive fluorometry of heat-stable alkaline phosphatase (Regan enzyme) activity in serum from smokers and nonsmokers.吸烟者和非吸烟者血清中热稳定碱性磷酸酶（雷根酶）活性的灵敏荧光测定法。
Clin Chem. 1983 Feb;29(2):260-3.
6
A search for trace expression of placental-like alkaline phosphatase in non-malignant human tissues: demonstration of its occurrence in lung, cervix, testis and thymus.在非恶性人体组织中寻找胎盘样碱性磷酸酶的微量表达：证实其在肺、宫颈、睾丸和胸腺中的存在。
Clin Chim Acta. 1982 Oct 13;125(1):63-75. doi: 10.1016/0009-8981(82)90046-8.
7
The genetic basis of alkaline phosphatase isozyme expression.碱性磷酸酶同工酶表达的遗传基础。
Isozymes Curr Top Biol Med Res. 1982;6:93-117.
8
Demonstration of placental and placental-like alkaline phosphatase in non-malignant human tissue extracts using monoclonal antibodies in an enzyme immunoassay.在酶免疫测定中使用单克隆抗体在非恶性人类组织提取物中检测胎盘和胎盘样碱性磷酸酶。
Clin Chim Acta. 1984 Mar 13;137(3):341-8. doi: 10.1016/0009-8981(84)90122-0.
9
Placental-type alkaline phosphatase in pregnancy and malignancy plasma: specific estimation using a monoclonal antibody in a solid phase enzyme immunoassay.孕期及恶性肿瘤患者血浆中的胎盘型碱性磷酸酶：在固相酶免疫测定中使用单克隆抗体进行特异性评估。
Clin Chim Acta. 1983 May 30;130(2):199-209. doi: 10.1016/0009-8981(83)90117-1.
10
Elevation of serum placental alkaline phosphatase levels in cigarette smokers.吸烟者血清胎盘碱性磷酸酶水平升高。
Int J Cancer. 1983 Jan 15;31(1):51-3. doi: 10.1002/ijc.2910310109.