Tan R S, MacLeod T I, Dean S G
Br J Dermatol. 1987 Jan;116(1):67-77. doi: 10.1111/j.1365-2133.1987.tb05792.x.
Using a standard technique involving monoclonal antibodies against T-cell subsets, we have shown that almost all the infiltrating T-cells in the epidermis of a patient with Pagetoid reticulosis (PR), one with epidermotropic mycosis fungoides (EMF) and one with poikiloderma atrophicans vasculare (PAV), were OKT8 positive (presumed cytotoxic/suppressor) T-cells. The infiltrating T-cells in the epidermis of a patient with limited plaque stage mycosis fungoides (MF), however, were almost exclusively Leu 3a-positive (presumed helper/inducer) T-cells as is usually found in this condition. The keratinocytes in the patients with PR, EMF and PAV were HLA-DR-positive whilst those in the patient with MF were HLA-DR-negative. We consider these four diseases to be part of the spectrum of mycosis fungoides, the first three conditions representing the early or benign end of the spectrum.
运用一种涉及针对T细胞亚群的单克隆抗体的标准技术，我们发现，在一名帕哲样网状细胞增生症（PR）患者、一名亲表皮性蕈样肉芽肿（EMF）患者和一名血管萎缩性皮肤异色病（PAV）患者的表皮中，几乎所有浸润性T细胞都是OKT8阳性（推测为细胞毒性/抑制性）T细胞。然而，在一名局限性斑块期蕈样肉芽肿（MF）患者的表皮中，浸润性T细胞几乎全是Leu 3a阳性（推测为辅助/诱导性）T细胞，这在该病症中通常可见。PR、EMF和PAV患者的角质形成细胞HLA-DR呈阳性，而MF患者的角质形成细胞HLA-DR呈阴性。我们认为这四种疾病是蕈样肉芽肿谱系的一部分，前三种情况代表了该谱系的早期或良性阶段。
