沙特阿拉伯西部地区甲状腺癌的18年研究：社区医院的一项回顾性单中心研究
An 18-year study of thyroid carcinoma in the western region of Saudi Arabia: a retrospective single-center study in a community hospital.
作者信息
Aljabri Khalid S, Bokhari Samia A, Al Muneera A, Khan Patan Murthuza
机构信息
Dr. Khalid S. Aljabri, Department of Endocrinology,, King Fahd Armed Forces Hospital,, PO Box 6572, Jeddah 24361,, Saudi Arabia, T: +966-555-544919, khalidsaljabri@ yahoo.com, ORCID: http://orcid. org/0000-0001-5831-5935.
出版信息
Ann Saudi Med. 2018 Sep-Oct;38(5):336-343. doi: 10.5144/0256-4947.2018.336.
BACKGROUND
Thyroid carcinoma (TC) is the ninth most common site of all cancers in women in the world and the second most common malignancy in Saudi Arabia. This reports updates data on the epidemiology of the disease in Saudi Arabia.
OBJECTIVE
Describe and interpret changes in the frequency of TC to compare with other populations and determine proportions of certain histological types of TC.
DESIGN
Medical record review.
SETTING
Military hospital in Jeddah, Saudi Arabia.
PATIENTS AND METHODS
We reviewed the pathological and clinical records from January 2000 to December 2017 of patients with TC.
MAIN OUTCOME MEASURES
Frequency and types of TC.
SAMPLE SIZE
347 patients.
RESULTS
Over the 18-year period, out of 456 patients with TC, 347 patients had sufficiently complete records: 275 (79.3%) were female and 72 (20.7%) were male for a female to male ratio of 3.8:1. The mean (SD) age at surgery of all patients was 45.2 (16.0) years. There were 287 (82.7%) cases of papillary TC. The next common malignancy was follicular TC with 32 (9.2%) cases followed by Hurthle cell cancer with 11 (3.2%) cases. Lymphoma was found in only 7 (2%) cases. All TC types occurred at a younger age in females than males except for lymphoma. All TC types occurred with the greatest frequency in the fourth and fifth decades. There was a 2.3-fold increase in the number of TCs from 8 (2.3%) in 2000 to 26 (7.5%) in 2017. The rate per 100000 residents of Jeddah increased for the period from 2000 to 2002 from 1.6 to 3.4 for 2015-2017. Papillary TC cases in females accounted for most of the increase.
CONCLUSION
Our findings are consistent with similar studies worldwide. Etiological factors promoting the rise in TC must be investigated and may provide insight in developing suitable management strategies for the Saudi population.
LIMITATION
Small sample size and retrospective over a long period.
CONFLICT OF INTEREST
None.
背景
甲状腺癌（TC）是全球女性中所有癌症的第九大常见发病部位，在沙特阿拉伯是第二大常见恶性肿瘤。本报告更新了沙特阿拉伯该疾病的流行病学数据。
目的
描述并解释TC发病率的变化，以便与其他人群进行比较，并确定某些组织学类型的TC所占比例。
设计
病历回顾。
地点
沙特阿拉伯吉达的一家军事医院。
患者与方法
我们回顾了2000年1月至2017年12月期间TC患者的病理和临床记录。
主要观察指标
TC的发病率和类型。
样本量
347例患者。
结果
在这18年期间，456例TC患者中，347例患者有足够完整的记录：女性275例（79.3%），男性72例（20.7%），男女比例为3.8:1。所有患者手术时的平均（标准差）年龄为45.2（16.0）岁。有287例（82.7%）乳头状TC病例。其次常见的恶性肿瘤是滤泡状TC，有32例（9.2%），其次是许特耳细胞癌，有11例（3.2%）。仅7例（2%）发现淋巴瘤。除淋巴瘤外，所有TC类型在女性中的发病年龄均比男性小。所有TC类型在第四和第五个十年中发病率最高。TC的数量从2000年的8例（2.3%）增加到2017年的26例（7.5%），增长了2.3倍。2000年至2002年期间，吉达每10万居民中的发病率从1.6上升到2015 - 2017年的3.4。女性乳头状TC病例的增加占了大部分。
结论
我们的研究结果与全球类似研究一致。必须调查促使TC发病率上升的病因因素，这可能为为沙特人群制定合适的管理策略提供见解。
局限性
样本量小且为长期回顾性研究。
利益冲突
无。
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