Alzahrani Ali S, Alomar Haneen, Alzahrani Nada
King Faisal Specialist Hospital & Research Centre, Department of Medicine, Riyadh, Saudi Arabia; Department of Molecular Oncology, Riyadh, Saudi Arabia.
Research Centre, Jeddah, Saudi Arabia.
Int J Endocrinol. 2017;2017:8423147. doi: 10.1155/2017/8423147. Epub 2017 Feb 27.
Most data on differentiated thyroid cancer (DTC) came from the Western world. We describe its salient characteristics and outcome from a Middle Eastern country. . We studied all cases of TC seen during a 2-year period (2004-2005) seen at our institution. . A total of 600 consecutive cases of DTC with a median age at diagnosis of 39 years (5-85) and the female : male ratio of 459 : 141 (76.5% : 23.5%). The cases included classical papillary thyroid cancer (PTC) in 77%, follicular variant PTC in 13.3%, follicular thyroid cancer in 3.2%, and other rare subtypes 6.5%. Total or near-total thyroidectomy was performed in 93%, central and/or lateral neck dissection in 64.5% of cases, and radioactive iodine ablation in 82% of cases. Additional therapies were administered to 154 patients (25.7%). At a median follow-up period of 7.63 years (0.22-13.1), 318 patients (53.3%) were in excellent response, 147 (24.5%) having an indeterminate response, 55 (9.2%) biochemically incomplete, 33 (5.5%) structurally incomplete, and 27 (4.5%) unclassifiable. Twenty cases died secondary to DTC (disease-specific mortality 3.3%). . In Saudi Arabia, DTC is common and occurs at young age and predominantly in females. Although remission is common, persistent disease is also common but disease-specific mortality is low.
大多数关于分化型甲状腺癌（DTC）的数据来自西方世界。我们描述了一个中东国家DTC的显著特征和转归情况。我们研究了在我们机构2004年至2005年这两年期间所见的所有甲状腺癌病例。共有600例连续的DTC病例，诊断时的中位年龄为39岁（5至85岁），女性与男性比例为459∶141（76.5%∶23.5%）。病例包括77%的经典乳头状甲状腺癌（PTC）、13.3%的滤泡状变异型PTC、3.2%的滤泡状甲状腺癌以及6.5%的其他罕见亚型。93%的患者接受了全甲状腺切除或近全甲状腺切除，64.5%的病例进行了中央区和/或侧颈部淋巴结清扫，82%的病例进行了放射性碘消融。154例患者（25.7%）接受了额外治疗。中位随访期为7.63年（0.22至13.1年），318例患者（53.3%）反应良好，147例（24.5%）反应不确定，55例（9.2%）生化不完全缓解，33例（5.5%）结构不完全缓解，27例（4.5%）无法分类。20例患者死于DTC（疾病特异性死亡率为3.3%）。在沙特阿拉伯，DTC很常见，发病年龄较轻，且主要发生在女性中。虽然缓解很常见，但持续性疾病也很常见，但疾病特异性死亡率较低。
