Department of Pharmacy, University of Louisville Hospital, Louisville, Kentucky.
Dermatol Ther. 2019 Jan;32(1):e12758. doi: 10.1111/dth.12758. Epub 2018 Oct 30.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life threatening cutaneous reactions that are most commonly caused by exposure to medications. This review assesses the efficacy and safety of cyclosporine therapy for SJS, TEN, and SJS/TEN overlap. A literature review was conducted in PubMed using the MeSH terms TEN, SJS, and cyclosporine. Five case series and one meta-analysis were analyzed. From review of the existing literature, cyclosporine appears to not only have a mortality benefit in the treatment of SJS/TEN, but also a relatively safe side effect profile.
史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）是罕见但危及生命的皮肤反应，最常见于暴露于药物。本综述评估了环孢素治疗 SJS、TEN 和 SJS/TEN 重叠的疗效和安全性。在 PubMed 中使用 MeSH 术语 TEN、SJS 和环孢素进行了文献复习。分析了 5 项病例系列研究和 1 项荟萃分析。从现有文献综述来看，环孢素不仅在治疗 SJS/TEN 方面具有降低死亡率的益处，而且具有相对安全的副作用谱。
