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肾血管阻力指数在高血压儿童中显著升高,且与脉压和左心室质量指数独立相关。

Renal resistive index significantly increased in hypertensive children and it is independently related to the pulse pressure and left ventricular mass index.

机构信息

a Department of Pediatric Cardiology, University of Health Sciences - Adana Health Practice and Research Center , Adana , Turkey.

b Department of Radiology, University of Health Sciences - Adana Health Practice and Research Center , Adana , Turkey.

出版信息

Clin Exp Hypertens. 2019;41(7):607-614. doi: 10.1080/10641963.2018.1523920. Epub 2018 Oct 4.

Abstract

: To the best our knowledge there is no data in the literature related to changes in renal resistive index (RRI) values in children who have hypertension (HT). In this study, we aimed to investigate the changes of RRI values and it is usability in children with HT. : A total of 75 children; 48 with newly diagnosed HT and 27 healthy controls were included in the study. Routine history, physical examination, and laboratory examinations were performed. Left ventricular (LV) dimensions and systolic-diastolic functions, septum and posterior wall thickness (IVSd and PWd) and LV mass index (LVMI) were calculated by echocardiography. In addition to routine renal ultrasonography (US), renal pulsatility indexes (RPI), accelerated time and RRI were measured. Increased RRI was accepted as >0.70. : Increased RRI was detected in 25 (52%) of HT patients. Systolic and diastolic blood pressure (SBP and DBP), and pulse pressure (PP), low-density lipoprotein cholesterol and triglyceride levels, RRI, RPI, kidney length, IVSd, PWd, and LVMI were significantly higher in patients with HT (both p < 0.05). SBP and PP, PWd, LV ejection fraction, LV fractional shortening, and LVMI were positively correlated with the RRI. High-density lipoprotein cholesterol was negatively correlated with the RRI. Of these measurements, RRI values were found to be independently associated with PP and LVMI (p < 0.05). : In hypertensive children, RRI was significantly higher than healthy controls and it is also related with LVMI and PP.

摘要

据我们所知,目前文献中尚无关于高血压儿童肾血管阻力指数(RRI)值变化的相关数据。在这项研究中,我们旨在研究 RRI 值的变化及其在高血压儿童中的可用性。

共纳入 75 名儿童,其中 48 名患有新诊断的高血压,27 名健康儿童作为对照组。进行了常规病史、体格检查和实验室检查。通过超声心动图计算左心室(LV)的大小和收缩-舒张功能、室间隔和后壁厚度(IVSd 和 PWd)和 LV 质量指数(LVMI)。除了常规的肾脏超声检查(US),还测量了肾脉动指数(RPI)、加速度时间和 RRI。将 RRI 增加定义为>0.70。

在 25 名(52%)高血压患者中发现 RRI 增加。高血压患者的收缩压和舒张压(SBP 和 DBP)、脉压(PP)、低密度脂蛋白胆固醇和甘油三酯水平、RRI、RPI、肾长、IVSd、PWd 和 LVMI 均显著高于对照组(均 p<0.05)。SBP 和 PP、PWd、LV 射血分数、LV 缩短分数和 LVMI 与 RRI 呈正相关。高密度脂蛋白胆固醇与 RRI 呈负相关。在这些测量中,RRI 值与 PP 和 LVMI 独立相关(p<0.05)。

在高血压儿童中,RRI 明显高于健康对照组,且与 LVMI 和 PP 相关。

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