Ajiboye B O, Oloyede H O B, Salawu M O
Department of Biochemistry, Faculty of Life Sciences, University of Ilorin, Nigeria.
Department of Chemical Sciences, College of Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
J Diet Suppl. 2020;17(2):133-149. doi: 10.1080/19390211.2018.1492485. Epub 2018 Oct 4.
The antidiabetic activity of seed-based diet on alloxan-induced diabetic rats was investigated. Forty-eight male and female albino rats of four groups were used for this study. Rats were sacrificed on day 28 and organs of interest were excised. seed-based diet significantly ( < .05) reversed the levels of fasting blood glucose, albumin, globulin, bilirubin, urea, creatinine, Na, and K. In addition, diabetic rats fed seed-based diet had significantly ( < .05) increased insulin and glycogen concentrations, activities of hexokinase, catalase, superoxide dismutase, and glutathione peroxidase and the levels of hematological parameters studied. Diabetic rats fed on seed had significantly ( < .05) reduced activities of glucose-6-phosphatase and fructose 1,6-diphosphatase and concentration of MDA and reversed activities of AST and GGT; ALP and regeneration of liver, kidney, and pancreas tissues compared favorably with the control group from histological examination results. Consumption of this diet may be useful for diabetes mellitus patients in ameliorating diabetes mellitus and its complications.
研究了基于种子的饮食对四氧嘧啶诱导的糖尿病大鼠的抗糖尿病活性。本研究使用了四组共48只雄性和雌性白化大鼠。在第28天处死大鼠，并切除感兴趣的器官。基于种子的饮食显著（<0.05）逆转了空腹血糖、白蛋白、球蛋白、胆红素、尿素、肌酐、钠和钾的水平。此外，喂食基于种子的饮食的糖尿病大鼠的胰岛素和糖原浓度、己糖激酶、过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶的活性以及所研究的血液学参数水平显著（<0.05）升高。喂食种子的糖尿病大鼠的葡萄糖-6-磷酸酶和果糖1,6-二磷酸酶的活性以及丙二醛的浓度显著（<0.05）降低，天冬氨酸转氨酶和γ-谷氨酰转移酶的活性逆转；从组织学检查结果来看，碱性磷酸酶以及肝、肾和胰腺组织的再生与对照组相比具有优势。食用这种饮食可能对糖尿病患者改善糖尿病及其并发症有用。
