在灌流脑片上测量大鼠嗅球中去甲肾上腺素释放的局部γ-氨基丁酸能调节。

Local GABAergic modulation of noradrenaline release in the rat olfactory bulb measured on superfused slices.

作者信息

Gervais R

出版信息

Brain Res. 1987 Jan 1;400(1):151-4. doi: 10.1016/0006-8993(87)90663-9.

Abstract

Ascending noradrenergic projections from locus coeruleus reaching the rat olfactory bulb (OB) synapse onto gamma-aminobutyric acid (GABA)-ergic interneurons. We tested the hypothesis that these interneurons could locally modulate noradrenaline (NA) release. On superfused OB slices, GABA (10, 100 and 1000 microM) enhanced potassium-evoked release of newly accumulated [3H]NA. This raises the possibility that GABAergic interneurons could establish a functional link between olfactory deutoneuron activity and NA release in the rat OB.

摘要

从蓝斑发出的去甲肾上腺素能上行投射到达大鼠嗅球（OB），并与γ-氨基丁酸（GABA）能中间神经元形成突触。我们检验了这样一个假设，即这些中间神经元可以局部调节去甲肾上腺素（NA）的释放。在经表面灌流的OB脑片上，GABA（10、100和1000微摩尔）增强了钾离子诱发的新积累的[3H]NA的释放。这增加了一种可能性，即GABA能中间神经元可能在大鼠OB的嗅觉第二级神经元活动和NA释放之间建立功能联系。