Department of Laboratorial Science and Technology, School of Public Health, Peking University, No. 38 Xue-Yuan Road, Haidian District, Beijing 100191, PR China.
Graduate School of Peking Union Medical College, Beijing 100730, China.
Psychiatry Res. 2018 Dec;270:306-309. doi: 10.1016/j.psychres.2018.09.056. Epub 2018 Sep 23.
Schizophrenia is a major psychiatric disorder with complex genetic, environmental, and psychological etiologies. Although DISC1 gene has been shown as a risk factor for schizophrenia in some reports, there is a lack of a consensus. We therefore performed separate meta-analyses aiming to assess the associations between DISC1 SNPs and schizophrenia risk. We found that SNP rs821597 is significantly associated with schizophrenia risk in terms of both allelic and genotypic distribution, while SNP rs821616 is associated with schizophrenia in terms of genotypic distribution, especially in cases above 40 years old.
精神分裂症是一种主要的精神疾病，具有复杂的遗传、环境和心理病因。虽然一些研究报告表明 DISC1 基因是精神分裂症的一个风险因素，但目前尚未达成共识。因此，我们进行了单独的荟萃分析，旨在评估 DISC1 SNPs 与精神分裂症风险之间的关联。我们发现，SNP rs821597 在等位基因和基因型分布两方面均与精神分裂症风险显著相关，而 SNP rs821616 仅在基因型分布方面与精神分裂症相关，尤其是在 40 岁以上的病例中。
