Nussberger J, Brunner D B, Waeber B, Biollaz J, Brunner H R
Clin Sci (Lond). 1987 Mar;72(3):387-9. doi: 10.1042/cs0720387.
In nine normal volunteers, a series of five venous blood samples was obtained before and up to 24 h after converting enzyme inhibition by a single oral dose of enalapril or lisinopril. Plasma renin activity and blood angiotensin I were measured. A close linear relationship was found between the increase in plasma renin activity and the increase in blood angiotensin I. The linear correlation between plasma renin activity and blood angiotensin I remained after converting enzyme inhibition. Thus, the rise in angiotensin I after inhibition of the conversion of angiotensin I to angiotensin II is due to an enhanced release of renin rather than to accumulation of angiotensin I.
在9名正常志愿者中，在单次口服依那普利或赖诺普利抑制转换酶之前及之后长达24小时内，采集了一系列5份静脉血样本。测量了血浆肾素活性和血中血管紧张素I。发现血浆肾素活性的增加与血中血管紧张素I的增加之间存在密切的线性关系。在转换酶抑制后，血浆肾素活性与血中血管紧张素I之间的线性相关性仍然存在。因此，在抑制血管紧张素I向血管紧张素II的转化后，血管紧张素I的升高是由于肾素释放增加而非血管紧张素I的积累所致。
