Bailly D, Dumont P, Dewailly D, Parquet P J
Encephale. 1986 Nov-Dec;12(6):309-14.
The HPA axis exploration in the endogenous depressions indicates an hyperactivity of this system. But the reason of this perturbation is not definite. The corticotropin-releasing factor (CRF) test has been described from research work carried out by Vale et al. In the endogenous depressions, this test enables us to specify physiopathological factors of the HPA axis dysfunction. Some research suggest an hypothalamic and limbic CRF hypersecretion in the endogenous depressions. But the results are not consistent principally because of the diversity of technical protocols. So the authors try to take stock of the CRF test specificity. They report the results obtained after 100 micrograms o-CRF intravenous administration in 7 voluntary normal men.
内源性抑郁症中下丘脑-垂体-肾上腺（HPA）轴的研究表明该系统存在功能亢进。但这种紊乱的原因尚不确定。促肾上腺皮质激素释放因子（CRF）试验是由Vale等人开展的研究工作中所描述的。在内源性抑郁症中，该试验使我们能够明确HPA轴功能障碍的生理病理因素。一些研究表明内源性抑郁症患者存在下丘脑和边缘系统CRF分泌过多的情况。但结果并不一致，主要是因为技术方案的多样性。因此，作者试图评估CRF试验的特异性。他们报告了7名自愿参与的正常男性静脉注射100微克邻位CRF后获得的结果。
