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通过丝裂原活化蛋白激酶相关信号传导探寻死亡相关蛋白激酶的新功能

Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals.

机构信息

Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.

Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Elqaliobiya, Toukh 13736, Egypt.

出版信息

Int J Mol Sci. 2018 Oct 4;19(10):3031. doi: 10.3390/ijms19103031.

DOI:10.3390/ijms19103031
PMID:30287790
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6213522/
Abstract

Death associated protein kinase (DAPK) is a calcium/calmodulin-regulated serine/threonine kinase; its main function is to regulate cell death. DAPK family proteins consist of DAPK1, DAPK2, DAPK3, DAPK-related apoptosis-inducing protein kinases (DRAK)-1 and DRAK-2. In this review, we discuss the roles and regulatory mechanisms of DAPK family members and their relevance to diseases. Furthermore, a special focus is given to several reports describing cross-talks between DAPKs and mitogen-activated protein kinases (MAPK) family members in various pathologies. We also discuss small molecule inhibitors of DAPKs and their potential as therapeutic targets against human diseases.

摘要

死亡相关蛋白激酶（DAPK）是一种钙/钙调蛋白调节的丝氨酸/苏氨酸激酶；其主要功能是调节细胞死亡。DAPK 家族蛋白包括 DAPK1、DAPK2、DAPK3、DAPK 相关凋亡诱导蛋白激酶（DRAK）-1 和 DRAK-2。在这篇综述中，我们讨论了 DAPK 家族成员的作用和调节机制及其与疾病的相关性。此外，我们特别关注了一些描述 DAPKs 与丝裂原活化蛋白激酶（MAPK）家族成员在各种病理中的相互作用的报告。我们还讨论了 DAPKs 的小分子抑制剂及其作为治疗人类疾病的潜在靶点的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e79e/6213522/9bdf80340a65/ijms-19-03031-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e79e/6213522/c4166c0426f2/ijms-19-03031-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e79e/6213522/94b5f74e8e58/ijms-19-03031-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e79e/6213522/9e58bda4a63d/ijms-19-03031-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e79e/6213522/a300e10ac3c2/ijms-19-03031-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e79e/6213522/9bdf80340a65/ijms-19-03031-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e79e/6213522/c4166c0426f2/ijms-19-03031-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e79e/6213522/94b5f74e8e58/ijms-19-03031-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e79e/6213522/9e58bda4a63d/ijms-19-03031-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e79e/6213522/a300e10ac3c2/ijms-19-03031-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e79e/6213522/9bdf80340a65/ijms-19-03031-g005.jpg

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