高血压中与连接肌浆网分离的二氢吡啶位点。

Dihydropyridine sites separate from junctional sacroplasmic reticulum in hypertension.

作者信息

Brandt N, Gelband C, Bassett A L

出版信息

Eur J Pharmacol. 1986 Nov 19;131(2-3):265-8. doi: 10.1016/0014-2999(86)90580-7.

DOI:10.1016/0014-2999(86)90580-7

Abstract

Distribution patterns on linear sucrose gradients for dihydropyridine (DHP) binding sites and Mr 300K polypeptides marker for junctional sarcoplasmic reticulum were determined in left ventricular microsomes of control and chronically pressure-overloaded cat hearts. Major peak of DHP sites corresponded in position and shape to distribution of Mr 300K polypeptide in controls but appeared at a lighter buoyant density in hypertrophy, similar to junctional plasma membrane (T-tubules) isolated from normal microsomes by French press treatment of dyad fraction.

摘要

在对照和慢性压力超负荷猫心脏的左心室微粒体中，测定了二氢吡啶（DHP）结合位点在线性蔗糖梯度上的分布模式以及连接肌浆网的300K道尔顿多肽标志物。在对照中，DHP位点的主要峰在位置和形状上与300K道尔顿多肽的分布相对应，但在肥大时出现在较轻的浮力密度处，类似于通过对二联体部分进行法式压榨处理从正常微粒体中分离出的连接质膜（T小管）。

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