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Antagonism of the ATP component of sympathetic co-transmission in the rat vas deferens by AMP.

作者信息

Satchell D

出版信息

Eur J Pharmacol. 1986 Dec 16;132(2-3):305-8. doi: 10.1016/0014-2999(86)90621-7.

DOI:10.1016/0014-2999(86)90621-7
PMID:3028840
Abstract

Field stimulation of isolated rat vas deferens preparations caused a twitch contraction followed by a slower phasic contraction. Exogenously applied ATP and noradrenaline caused rapid contractions and slowly developing contractions respectively. Pretreatment with phentolamine antagonised the phasic response to stimulation and the contraction to noradrenaline. Pretreatment with AMP antagonized the twitch response to stimulation and concentrations to ATP. The results support the view that ATP is released as a co-transmitter with noradrenaline in sympathetic nerves.

摘要

相似文献

1
Antagonism of the ATP component of sympathetic co-transmission in the rat vas deferens by AMP.
Eur J Pharmacol. 1986 Dec 16;132(2-3):305-8. doi: 10.1016/0014-2999(86)90621-7.
2
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J Pharmacol Exp Ther. 2001 Aug;298(2):623-33.

引用本文的文献

1
Pertussis toxin does not attenuate alpha 2-adrenoceptor mediated inhibition of noradrenaline release in mouse atria.百日咳毒素不会减弱α2 - 肾上腺素能受体介导的对小鼠心房去甲肾上腺素释放的抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Sep;336(3):280-6. doi: 10.1007/BF00172679.
2
The mechanism of action of AMP-induced inhibition of sympathetic neurotransmission in the isolated vas deferens of the rat and guinea-pig.AMP诱导大鼠和豚鼠离体输精管交感神经传递抑制的作用机制。
Br J Pharmacol. 1988 Jul;94(3):961-7. doi: 10.1111/j.1476-5381.1988.tb11610.x.
3
An ATP-sensitive conductance in single smooth muscle cells from the rat vas deferens.
大鼠输精管单个平滑肌细胞中的ATP敏感性电导。
J Physiol. 1988 Jul;401:361-80. doi: 10.1113/jphysiol.1988.sp017167.