Ahmadi-Motamayel Fatemeh, Vaziri-Amjad Samaneh, Davoodi Poorandokht, Goodarzi Mohammad T, Poorolajal Jalal
Dental Implant Research Center and Dental Research Center, Department of Oral Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Oral Medicine, Dental School, Hamadan University of Medical Sciences, Hamadan, Iran.
Infect Disord Drug Targets. 2019;19(4):398-402. doi: 10.2174/1871526518666181005120804.
Saliva is a very important complex biological oral fluid .Antioxidants are present in all body fluids. Uric acid, albumin and vitamins are some of the non- enzymatic molecular antioxidants. Alkaline phosphatase is related to cell injury and death.
The aim of this study was the evaluation of salivary alkaline phosphatase and albumin level in HIV positive patients in comparison to healthy control group.
Case groups were 49 HIV positive subjects, compared with 49 healthy control group. Oral clinical examination was carried out. Five ml unstimulated whole saliva was collected during 5 min with the Navazesh method. Alkaline phosphatase was determined by spectrophotometric assay. Albumin was assessed by the nephelometric method.
The results of this study showed significantly lower salivary albumin in the case group in comparison to healthy control group (p= 0.001). HIV positive group had greater alkaline phosphatase than the healthy control group. However, this difference was not statistically significant (p=0.458).
Salivary albumin level was significantly decreased and salivary alkaline phosphatase level slightly increased in HIV positive patients in comparison to healthy control group. All of the HIV infected patients were in early phase of HIV infection with normal immune status. More research is needed to estimate these enzymes changes in late phase of HIV infection and AIDS step.
唾液是一种非常重要的复杂生物口腔液体。抗氧化剂存在于所有体液中。尿酸、白蛋白和维生素是一些非酶分子抗氧化剂。碱性磷酸酶与细胞损伤和死亡有关。
本研究的目的是评估HIV阳性患者与健康对照组相比唾液碱性磷酸酶和白蛋白水平。
病例组为49名HIV阳性受试者，与49名健康对照组进行比较。进行口腔临床检查。采用纳瓦泽什法在5分钟内收集5毫升非刺激性全唾液。通过分光光度法测定碱性磷酸酶。通过比浊法评估白蛋白。
本研究结果显示，病例组唾液白蛋白水平显著低于健康对照组（p = 0.001）。HIV阳性组的碱性磷酸酶高于健康对照组。然而，这种差异无统计学意义（p = 0.458）。
与健康对照组相比，HIV阳性患者唾液白蛋白水平显著降低，唾液碱性磷酸酶水平略有升高。所有HIV感染患者均处于HIV感染早期，免疫状态正常。需要更多研究来评估HIV感染晚期和艾滋病阶段这些酶的变化。
