Fleming S, Gibson A A
Histopathology. 1986 Dec;10(12):1303-13. doi: 10.1111/j.1365-2559.1986.tb02573.x.
The proteinase inhibitors alpha-1-antitrypsin and alpha-1-antichymotrypsin are found in a variety of tissues including the kidney. We have used the immunoperoxidase technique to study the distribution of these glycoproteins in 10 fetal and five adult kidneys and in 44 renal tumours. Proteinase inhibitors were found in fetal kidneys in the cells of the metanephric blastema, primitive mesenchyme and in proximal tubules. They were found in proximal tubules of adult kidneys. These substances were also found in the mesenchyme of nephroblastomas and in the tumour cells of clear cell, oncocytic and sarcomatoid variants of renal cell carcinoma. These observations are significant in the understanding of the patterns of differentiation of which renal cell carcinoma is capable.
蛋白酶抑制剂α-1-抗胰蛋白酶和α-1-抗糜蛋白酶存在于包括肾脏在内的多种组织中。我们采用免疫过氧化物酶技术研究了这些糖蛋白在10个胎儿肾脏、5个成人肾脏以及44个肾肿瘤中的分布情况。在胎儿肾脏的后肾胚基细胞、原始间充质细胞和近端小管中发现了蛋白酶抑制剂。在成人肾脏的近端小管中也发现了它们。在肾母细胞瘤的间充质以及肾细胞癌透明细胞、嗜酸细胞和肉瘤样变体的肿瘤细胞中也发现了这些物质。这些观察结果对于理解肾细胞癌能够发生的分化模式具有重要意义。
