Gafarov V V, Gromova E A, Gagulin I V, Panov D O, Gafarova A V
Klin Med (Mosk). 2016;94(8):601-8.
To characterize differences in the risk of development (RD) of myocardial infarction (MI) and stroke during 16 years in an open Siberian population aged 25-64 years and suffering vital exhaustion (VE).
We examined a random representative sample of 657 men and 870 women from the Novosibirsk population in the framework of the WHO «MONICA-psychosocial» screening III program (1954). It included registration of socio-demographic data and cases of VE. A total of 15 episodes of MI and 35 strokes were documented in 30 women and 22 men.
The level of VE in men was 66,8% (high in 14,6%), in women75,7% (high in 44,4%). RD of MI estimated from the relative risk (RR) in men with VE(RR=2) was higher than in women. It was higher in divorced women (RR=5,4) than in men (RR=4,7). RD of MI was higher in men with VE (OR=2,2 in subjects having elementary education, OR=3,7 in bachelors, OR = 7 in widowers;at the age from 45 to 54 years OR=3,8, at the age from 55 to 64 years OR=5,9) than in women. The overall RD of stroke in subjects of either sex with VE was not significantly different (OR=3,34 in women and 3,1). However, it was higher than in women in men with VE having partially completed secondary-level and elementary education RR=4.8), in divorced and widowed men (RR=3.8 and 3.6 respectively.
The study showed that the prevalence of VE in the population aged 25-64yearsis higher than in other age groups and higher in women than in men. VE is a more reliable predictor of MI in men than in women; it is a predictor of stroke in either sexes.
描述25 - 64岁患有严重疲劳（VE）的西伯利亚开放人群在16年中心肌梗死（MI）和中风发生风险（RD）的差异。
在世界卫生组织“MONICA - 社会心理”筛查III项目（1954年）框架内，我们对新西伯利亚人群中657名男性和870名女性的随机代表性样本进行了检查。该项目包括社会人口统计学数据和VE病例的登记。在30名女性和22名男性中记录了总共15次心肌梗死发作和35次中风。
男性的VE水平为66.8%（14.6%为高水平），女性为75.7%（44.4%为高水平）。从患有VE的男性的相对风险（RR = 2）估计的MI的RD高于女性。离婚女性（RR = 5.4）高于男性（RR = 4.7）。患有VE的男性的MI的RD高于女性（小学文化程度的受试者中OR = 2.2，学士中OR = 3.7，鳏夫中OR = 7；45至54岁时OR = 3.8，55至64岁时OR = 5.9）。患有VE的男女中风的总体RD无显著差异（女性中OR = 3.34，男性中OR = 3.1）。然而，在部分完成中等教育和小学教育的患有VE的男性中（RR = 4.8）、离婚和丧偶男性中（RR分别为3.8和3.6），其高于女性。
研究表明，25 - 64岁人群中VE的患病率高于其他年龄组，女性高于男性。VE对男性MI的预测比女性更可靠；它是男女中风的预测指标。
