血浆有机氯水平与多发性骨髓瘤风险。
Organochlorine Levels in Plasma and Risk of Multiple Myeloma.
机构信息
BC Cancer, Vancouver, British Columbia, Canada (Drs Weber, Song, Ms Lai, Drs Sutherland, Spinelli); University of South Australia, Adelaide, South Australia, Australia (Dr Boyle); and Institut National de Santé Publique de Québec (INSPQ) / Centre de Toxicologie de Québec, Québec, Quebec, Canada (Mr Gaudreau, Dr LeBlanc).
出版信息
J Occup Environ Med. 2018 Oct;60(10):911-916. doi: 10.1097/JOM.0000000000001387.
OBJECTIVE
The aim of this study was to estimate the association between organochlorine pesticides and polychlorinated biphenyls (PCBs) and multiple myeloma (MM).
METHODS
The risk of MM from organochlorine compounds was examined in a population-based case-control study in British Columbia, Canada. Congeners of PCBs and pesticides or pesticide metabolites were measured in plasma of 325 cases and 327 controls.
RESULTS
Most organochlorine analytes showed a significant association with MM. The strongest association (highest vs lowest quartile) was oxychlordane (odds ratio = 7.44; 95% confidence interval = 4.19 to 13.21). No heterogeneity was detected between organochlorines levels and MM subtypes. Only oxychlordane and β-hexachlorocyclohexane (β-HCCH) were identified as significant independent predictors of MM.
CONCLUSION
Our study provides evidence that organochlorines contribute to the risk of MM.
目的
本研究旨在评估有机氯农药和多氯联苯（PCBs）与多发性骨髓瘤（MM）之间的关联。
方法
在加拿大不列颠哥伦比亚省进行了一项基于人群的病例对照研究，以检查有机氯化合物与 MM 的风险。在 325 例病例和 327 例对照的血浆中测量了 PCBs 和农药或农药代谢物的同系物。
结果
大多数有机氯分析物与 MM 呈显著关联。最强的关联（最高与最低四分位组相比）是氧氯丹（比值比=7.44；95%置信区间=4.19 至 13.21）。在有机氯水平和 MM 亚型之间未检测到异质性。只有氧氯丹和β-六氯环己烷（β-HCCH）被确定为 MM 的显著独立预测因子。
结论
我们的研究提供了证据，表明有机氯化合物会增加 MM 的风险。
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