Goldmann Jakob M, Wong Wendy S W, Pinelli Michele, Farrah Terry, Bodian Dale, Stittrich Anna B, Glusman Gustavo, Vissers Lisenka E L M, Hoischen Alexander, Roach Jared C, Vockley Joseph G, Veltman Joris A, Solomon Benjamin D, Gilissen Christian, Niederhuber John E
Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Inova Translational Medicine Institute (ITMI), Inova Health Systems, Falls Church, Virginia, USA.
Nat Genet. 2018 Nov;50(11):1615. doi: 10.1038/s41588-018-0226-5.
In the version of this article published, the P values for the enrichment of single mutation categories were inadvertently not corrected for multiple testing. After multiple-testing correction, only two of the six mutation categories mentioned are still statistically significant. To reflect this, the text "More specifically, paternally derived DNMs are enriched in transitions in A[.]G contexts, especially ACG>ATG and ATG>ACG (Bonferroni-corrected P = 1.3 × 10 and P = 1 × 10, respectively). Additionally, we observed overrepresentation of ATA>ACA mutations (Bonferroni-corrected P = 4.28 × 10) for DNMs of paternal origin. Among maternally derived DNMs, CCA>CTA, GCA>GTA and TCT>TGT mutations were significantly overrepresented (Bonferroni-corrected P = 4 × 10, P = 5 × 10, P = 1 × 10, respectively)" should read "More specifically, CCA>CTA and GCA>GTA mutations were significantly overenriched on the maternal allele (Bonferroni-corrected P = 0.0192 and P = 0.048, respectively)." Additionally, the last sentence to the legend for Fig. 3b should read "Green boxes highlight the mutation categories that differ significantly" instead of "Green boxes highlight the mutation categories that differ more than 1% of mutation load with a bootstrapping P value <0.05." Corrected versions of Fig. 3b and Supplementary Table 25 appear with the Author Correction.
在本文发表的版本中，单个突变类别的富集P值因疏忽未进行多重检验校正。经过多重检验校正后，提及的六个突变类别中只有两个在统计学上仍具有显著性。为反映这一点，文本“更具体地说，父源新发突变在A[.]G背景的转换中富集，尤其是ACG>ATG和ATG>ACG（分别为Bonferroni校正P = 1.3×10和P = 1×10）。此外，我们观察到父源新发突变中ATA>ACA突变存在过度代表性（Bonferroni校正P = 4.28×10）。在母源新发突变中，CCA>CTA、GCA>GTA和TCT>TGT突变显著过度代表性（分别为Bonferroni校正P = 4×10、P = 5×10、P = 1×10）”应改为“更具体地说，CCA>CTA和GCA>GTA突变在母源等位基因上显著过度富集（分别为Bonferroni校正P = 0.0192和P = 0.048）”。此外，图3b图例的最后一句话应改为“绿色框突出显示有显著差异的突变类别”，而不是“绿色框突出显示与突变负荷差异超过1%且自展P值<0.05的突变类别”。图3b和补充表25的校正版本随作者更正一同出现。
