Agricultural and Ecological Research Unit, Indian Statistical Institute, Kolkata - 700 108, West Bengal, India.
Department of Mathematics, University of Kalyani, Kalyani - 741 235, West Bengal, India.
Math Biosci. 2018 Dec;306:160-169. doi: 10.1016/j.mbs.2018.09.014. Epub 2018 Oct 3.
Infectious diseases can have a large impact on society, as they cause morbidity, mortality, unemployment, inequality and other adverse effects. Mathematical models are invaluable tools in understanding and describing disease dynamics with preventive measures for controlling the disease. The roles of media coverage and behavioral changes due to externally imposed factors on the disease dynamics are well studied. However, the effect of self-imposed psychological fear on the disease transmission has not been considered in extant research, and this gap is addressed in the present investigation. We propose a simple SI-type model for HIV/AIDS to assess the effects of media and self-imposed psychological fear on the disease dynamics. Local and global dynamics of the system are studied. Global sensitivity analysis is performed to identify the most influential parameters that have significant impact on the basic reproduction number. After calibrating our model using HIV case data-sets for Uganda and Tanzania, we calculate the basic reproduction numbers in the study period using the estimated parameters. Furthermore, a comparison of the effects of awareness and self-imposed psychological fear effects reveals that awareness is more effective in eliminating the burden of HIV infection.
传染病对社会有很大的影响,因为它们会导致发病率、死亡率、失业、不平等和其他不良后果。数学模型是理解和描述疾病动力学并采取预防措施控制疾病的宝贵工具。媒体报道的作用和由于外部因素引起的行为变化对疾病动力学的影响已经得到了很好的研究。然而,在现有的研究中,没有考虑到自我强加的心理恐惧对疾病传播的影响,本研究填补了这一空白。我们提出了一个简单的 HIV/AIDS 型 SI 模型,以评估媒体和自我强加的心理恐惧对疾病动力学的影响。研究了系统的局部和全局动力学。进行了全局敏感性分析,以确定对基本繁殖数有重大影响的最具影响力的参数。使用乌干达和坦桑尼亚的 HIV 病例数据集对我们的模型进行校准后,我们使用估计的参数计算了研究期间的基本繁殖数。此外,对意识和自我强加的心理恐惧的影响进行了比较,结果表明意识在消除 HIV 感染负担方面更有效。