Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Curr Opin Cell Biol. 2019 Feb;56:64-70. doi: 10.1016/j.ceb.2018.09.003. Epub 2018 Oct 3.
Cell migration is a critical process that underpins a number of physiological and pathological contexts such as the correct functioning of the immune system and the spread of metastatic cancer cells. Central to this process are the Rho family of GTPases, which act as core regulators of cell migration. Rho GTPases are molecular switches that associate with lipid membranes and act to choreograph molecular events that underpin cell migration. Specifically, these GTPases play critical roles in coordinating force generation through driving the formation of cellular protrusions as well as cell-cell and cell-matrix adhesions. Here we provide an update on the many roles of Rho-family GTPases in coordinating protrusion and adhesion formation in the context of cell migration, as well as describing how their activity is controlled to by a variety of complex signalling networks.
细胞迁移是一个关键的过程，它支持着许多生理和病理环境，如免疫系统的正常功能和转移性癌细胞的扩散。在这个过程中，Rho 家族 GTPases 是核心调节剂，它们作为分子开关与脂膜结合，协调细胞迁移的分子事件。具体来说，这些 GTPases 在协调力的产生方面发挥着关键作用，通过驱动细胞突起的形成以及细胞-细胞和细胞-基质黏附。在这里，我们提供了 Rho 家族 GTPases 在协调细胞迁移过程中突起和黏附形成方面的许多作用的最新信息，并描述了它们的活性是如何通过各种复杂的信号网络来控制的。
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