Graduate Program in Neuroscience, University of British Columbia, Vancouver, Canada.
MRI Research Facility, BC Children's Hospital, Vancouver, Canada.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Jan;4(1):39-49. doi: 10.1016/j.bpsc.2018.08.004. Epub 2018 Aug 25.
Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat depression during pregnancy. SSRIs cross the placenta, inhibit serotonin reuptake, and thereby are thought to alter central fetal serotonin signaling. Both prenatal maternal mood disturbances and in utero SSRI exposure have been associated with altered fetal and infant behavior. Resting-state functional magnetic resonance imaging has identified resting-state networks (RSNs) in newborns, reflecting functional capacity of auditory and visual networks and providing opportunities to examine early experiences effects on neurodevelopment. We sought to examine the effect of in utero SSRI exposure on neonatal RSN functional organization. We hypothesized that prenatal SSRI exposure would be associated with alterations in neonatal RSNs compared with healthy control infants and infants exposed to mothers with depression.
Clinician-rated Hamilton Depression Rating Scale and self-reported Pregnancy Experiences Scale were completed during the third trimester. Control (n = 17), maternal depression-exposed (Hamilton Depression Rating Scale ≥8 without SSRI exposure, n = 16), and SSRI-exposed (n = 20) 6-day-old neonates underwent resting-state functional magnetic resonance imaging. Independent component analysis was used as a data-driven approach to extract 22 RSNs.
SSRI-exposed neonates had higher connectivity in a putative auditory RSN compared with depressed-only (p = .01) and control (p = .02) infants (corrected for multiple comparisons), controlling for sex, age at the magnetic resonance imaging, and Pregnancy Experiences Scale score.
Hyperconnectivity in auditory RSN in neonates with in utero SSRI exposure relative to neonates of depressed but not pharmacologically treated mothers and control infants may offer an insight into the functional organization origins of shifts in language perception and altered language development, previously reported in infants and children with prenatal SSRI exposure.
选择性 5-羟色胺再摄取抑制剂（SSRIs）常用于治疗妊娠期抑郁症。SSRIs 可穿过胎盘，抑制 5-羟色胺再摄取，从而被认为会改变胎儿中枢 5-羟色胺信号。产前母体情绪障碍和宫内 SSRI 暴露都与胎儿和婴儿行为改变有关。静息态功能磁共振成像已在新生儿中识别出静息态网络（RSNs），反映了听觉和视觉网络的功能能力，并为研究早期经验对神经发育的影响提供了机会。我们试图研究宫内 SSRI 暴露对新生儿 RSN 功能组织的影响。我们假设与健康对照组婴儿和暴露于患有抑郁症的母亲的婴儿相比，产前 SSRI 暴露与新生儿 RSN 的改变有关。
在孕晚期完成临床医生评定的汉密尔顿抑郁量表和自我报告的妊娠经历量表。对照组（n=17）、母亲抑郁暴露组（汉密尔顿抑郁量表评分≥8 且未使用 SSRI 暴露，n=16）和 SSRI 暴露组（n=20）的 6 天大新生儿进行静息态功能磁共振成像。独立成分分析被用作一种数据驱动的方法来提取 22 个 RSN。
与仅抑郁组（p=0.01）和对照组（p=0.02）相比，SSRI 暴露组的新生儿在假定的听觉 RSN 中具有更高的连通性（校正多重比较），控制了性别、磁共振成像时的年龄和妊娠经历量表评分。
与抑郁但未接受药物治疗的母亲和对照组婴儿的新生儿相比，宫内 SSRI 暴露的新生儿在听觉 RSN 中存在过度连通性，这可能为语言感知和语言发育改变的功能组织起源提供了一些见解，这些改变在产前 SSRI 暴露的婴儿和儿童中已有报道。
