与小鼠实验性浆细胞瘤相关的周围神经病变

Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse.

作者信息

Nemni R, Fazio R, Corbo M, Sacchi C, Smirne S, Canal N

出版信息

J Neurol Sci. 1987 Feb;77(2-3):321-9. doi: 10.1016/0022-510x(87)90131-6.

Abstract

In order to investigate the role of paraproteins in the production of neuropathy we experimentally induced monoclonal immunoglobulin-producing tumours into 32 BALB/c mice by injecting mineral oil or pristane intraperitoneally. In 11 mice morphologic and histometric studies of the sciatic nerve revealed the presence of neuropathy. Immunohistochemical studies did not demonstrate a significant amount of immunoglobulins and light chains in the endoneurium. The advantages and limits of this experimental model are discussed.

摘要

为了研究副蛋白在神经病变产生中的作用，我们通过腹腔注射矿物油或 pristane ，在 32 只 BALB/c 小鼠中实验性诱导产生单克隆免疫球蛋白的肿瘤。在 11 只小鼠中，对坐骨神经的形态学和组织计量学研究显示存在神经病变。免疫组织化学研究未在内神经膜中发现大量免疫球蛋白和轻链。讨论了该实验模型的优点和局限性。