Li Z Q, Zheng Z H, Du W L, Pang L X, Li Y, Wu Z B, Zhu P
Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2018 Sep 24;46(9):713-718. doi: 10.3760/cma.j.issn.0253-3758.2018.09.008.
To explore the relation between platelet-to-lymphocyte ratio (PLR) or neutrophil-to-lymphocyte ratio (NLR) with disease activity in Takayasu arteritis (TA) patients. Present retrospective study involved 289 patients with TA, who were hospitalized in our department between January 2010 and October 2017, and 280 age and gender matched healthy controls,who underwent thealth examination in our health examination center during the same period (control group). TA patients were further divided into active and inactive groups (180 and 109 cases respectively) according to Kerr scores. The clinical data were compared between groups. Pearson correlation analysis was used to evaluate the relationship between PLR or NLR and disease activity (Kerr score or C-reactive protein or erythrocyte sedimentation rate). Receiver operating characteristic (ROC) curve was employed to judge the cut-off value of disease activity for TA patients. PLR and NLR were significantly higher in TA group than in control group(137.33 (97.38, 193.37) vs. 120.55 (96.86, 144.60) and 2.38 (1.76, 3.57) vs. 1.66 (1.35, 2.08) , respectively, all 0.001). PLR and NLR were significantly higher in active TA group than in inactive TA group (163.43 (123.64, 224.15) vs. 110.53 (84.22, 147.24) and 2.59 (1.96, 3.94) vs. 1.95 (1.53, 2.86) respectively, all 0.001). PLR and NLR of active group were significantly decreased after 6 months treatment (164.05 (123.29, 226.29) vs. 104.67 (77.22, 138.43) and 2.58 (1.96, 3.91) vs. 2.15 (1.67, 2.60) respectively, all 0.001). PLR was positively correlated with Kerr score (0.439, 0.001), C-reactive protein (0.328, 0.001) and erythrocyte sedimentation rate (0.410, 0.001). NLR also exhibited a positive relationship with Kerr score (0.235, 0.001), C-reactive protein (0.169, 0.005) and erythrocyte sedimentation rate (0.123, 0.037). A PLR level of 176.709 was shown to be the best predictive cut-off value for TA disease activity (sensitivity 44.6%, specificity 93.0%, and area under the curve=0.766).A NLR level of 2.128 was shown to be the best predictive cut-off value for TA disease activity (sensitivity 70.9%, specificity 47.7%, and area under the curve=0.691). PLR and NLR are useful markers for predicting disease activity of TA patients.
探讨血小板与淋巴细胞比值（PLR）或中性粒细胞与淋巴细胞比值（NLR）与大动脉炎（TA）患者疾病活动度之间的关系。本回顾性研究纳入了289例TA患者，这些患者于2010年1月至2017年10月在我科住院，以及280例年龄和性别匹配的健康对照者，他们于同一时期在我们的健康体检中心接受了健康检查（对照组）。TA患者根据克尔评分进一步分为活动组和非活动组（分别为180例和109例）。对各组临床资料进行比较。采用Pearson相关分析评估PLR或NLR与疾病活动度（克尔评分、C反应蛋白或红细胞沉降率）之间的关系。采用受试者工作特征（ROC）曲线判断TA患者疾病活动度的截断值。TA组的PLR和NLR显著高于对照组（分别为137.33（97.38，193.37）对120.55（96.86，144.60）以及2.38（1.76，3.57）对1.66（1.35，2.08），P均<0.001）。活动期TA组的PLR和NLR显著高于非活动期TA组（分别为163.43（123.64，224.15）对110.53（84.22，147.24）以及2.59（1.96，3.94）对1.95（1.53，2.86），P均<0.001）。活动组治疗6个月后PLR和NLR显著降低（分别为164.05（123.29，226.29）对104.67（77.22，138.43）以及2.58（1.96，3.91）对2.15（1.67，2.60），P均<0.001）。PLR与克尔评分（r=0.439，P=0.001）、C反应蛋白（r=0.328，P=0.001）和红细胞沉降率（r=0.410，P=0.001）呈正相关。NLR与克尔评分（r=0.235，P=0.001）、C反应蛋白（r=0.169，P=0.005）和红细胞沉降率（r=0.123，P=0.037）也呈正相关。PLR水平为176.709被证明是TA疾病活动度的最佳预测截断值（敏感性44.6%，特异性93.0%，曲线下面积=0.766）。NLR水平为2.128被证明是TA疾病活动度的最佳预测截断值（敏感性70.9%，特异性47.7%，曲线下面积=0.691）。PLR和NLR是预测TA患者疾病活动度的有用指标。
