Chest Department, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.
Pulmonology Department, Centro Hospitalar de Lisboa Central, Lisboa, Portugal.
Pulmonology. 2018 Sep-Oct;24(5):289-293. doi: 10.1016/j.pulmoe.2018.02.006. Epub 2018 Mar 17.
Ocular tuberculosis (OTB) is a rare form of tuberculosis. Diagnosis is usually presumptive based on epidemiology, clinical findings and positivity of immune response. The aim of the study was to characterize the OTB cases identified in Lisbon.
Retrospective study on OTB cases diagnosed in Lisbon from 2012 to 2015. The authors gathered data regarding demographic characteristics, diagnostic criteria, type of treatment as well as therapeutic results.
There were 39 reported cases of presumed OTB which accounted for 12.2% of all reported TB cases. Patients had a mean age of 55.5 years. All had ocular manifestations (mainly uveitis). Diagnostic criteria included positive tuberculin skin test (TST) and/or Interferon Gamma Release Assay (IGRA). Culture testing or PCR could not be determined in any patient. Patients had OTB treatment for an average of 9.08 months. Clinical improvement was reported in 91.4% of treated patients. There were no relapses.
This is the first published series about OTB in Lisbon. All cases had a presumptive diagnosis made through TST and/or IGRA testing. Most of treated patients improved, with no signs of relapse and a median 29.9-month follow up. OTB seems to be a growing diagnosis and treatment may be beneficial even in patients with a presumptive diagnosis.
眼部结核（OTB）是一种罕见的结核病形式。诊断通常基于流行病学、临床发现和免疫反应阳性来推测。本研究的目的是描述在里斯本发现的 OTB 病例的特征。
对 2012 年至 2015 年在里斯本诊断的 OTB 病例进行回顾性研究。作者收集了有关人口统计学特征、诊断标准、治疗类型以及治疗结果的数据。
报告了 39 例疑似 OTB 病例，占所有报告结核病病例的 12.2%。患者的平均年龄为 55.5 岁。所有患者均有眼部表现（主要为葡萄膜炎）。诊断标准包括结核菌素皮肤试验（TST）和/或干扰素释放试验（IGRA）阳性。任何患者的培养试验或 PCR 均无法确定。患者接受 OTB 治疗的平均时间为 9.08 个月。报告称 91.4%的治疗患者的临床状况有所改善。没有复发。
这是里斯本首次发表的 OTB 系列报道。所有病例均通过 TST 和/或 IGRA 检测进行推测性诊断。大多数接受治疗的患者病情改善，无复发迹象，中位随访时间为 29.9 个月。OTB 的诊断似乎越来越多，即使对推测性诊断的患者进行治疗也可能有益。
