Pradhan Roma, Agarwal Amit, Gupta Sushil Kumar
Department of Endocrine Surgery, Dr RMLIMS, Lucknow, Uttar Pradesh, India.
Department of Endocrinology, SGPGIMS, Lucknow, Uttar Pradesh, India.
Indian J Endocrinol Metab. 2018 Sep-Oct;22(5):705-709. doi: 10.4103/ijem.IJEM_54_18.
Primary hyperparathyroidism (PHPT) is an uncommon condition in children and adolescents. However, rapid growth spurt during puberty may result in unmasking and development of certain skeletal manifestations of PHPT. We present three cases of PHPT associated with rare skeletal manifestations of rickets. All three patients had radiological evidence of rickets with primary hyperparathyroidism. All the three patients had single gland adenoma. Literature is sparse regarding reversal of features of rickets following parathyroidectomy. In all three patients of our series, there was a complete resolution of bone/joint pain. However, in two children only the genu valgum persisted but their growth was normal and they had no proximal muscle weakness. In another child multiple corrective surgeries were done to correct the deformities.
原发性甲状旁腺功能亢进症（PHPT）在儿童和青少年中并不常见。然而，青春期快速生长突增可能导致PHPT某些骨骼表现的显现和发展。我们报告了3例与罕见佝偻病骨骼表现相关的PHPT病例。所有3例患者均有原发性甲状旁腺功能亢进症合并佝偻病的影像学证据。所有3例患者均为单发性腺瘤。关于甲状旁腺切除术后佝偻病特征逆转的文献较少。在我们系列研究的所有3例患者中，骨/关节疼痛均完全缓解。然而，在2名儿童中，仅膝外翻持续存在，但他们生长正常，且没有近端肌无力。在另一名儿童中，进行了多次矫正手术以纠正畸形。
