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一名有子宫内膜癌病史患者结肠中的苗勒管癌肉瘤：病例报告及对可能发病机制的见解。

Mullerian carcinosarcoma in the colon of a patient with history of endometrial carcinoma: A case report and insight into possible pathogenesis.

作者信息

Hemedez Claire Anne Therese, Lomme Michele, Ruhul Quddus M

机构信息

Department of Pathology, Women and Infants Hospital, Providence, RI 02905, USA.

出版信息

Gynecol Oncol Rep. 2018 Sep 24;26:49-52. doi: 10.1016/j.gore.2018.09.003. eCollection 2018 Nov.

DOI:10.1016/j.gore.2018.09.003
PMID:30294656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6171370/
Abstract

•Mullerian carcinosarcoma can occur in extragenital sites.•Malignant transformation of endometriosis is common in the rectosigmoid area.•MLH1 hypermethylation has been implicated in endometriosis-associated carcinomas.•Adequate sampling is essential in determining the etiology of colonic tumors.

摘要

•苗勒管癌肉瘤可发生于生殖器外部位。

•子宫内膜异位症的恶性转化在直肠乙状结肠区域很常见。

•MLH1高甲基化与子宫内膜异位症相关的癌有关。

•足够的取材对于确定结肠肿瘤的病因至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9802/6171370/c27019c4fcb9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9802/6171370/36102bf6ca48/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9802/6171370/746760df512d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9802/6171370/c27019c4fcb9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9802/6171370/36102bf6ca48/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9802/6171370/746760df512d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9802/6171370/c27019c4fcb9/gr3.jpg

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本文引用的文献

1
Carcinosarcomas and Related Cancers: Tumors Caught in the Act of Epithelial-Mesenchymal Transition.癌肉瘤及相关癌症：上皮-间充质转化过程中的肿瘤。
J Clin Oncol. 2018 Jan 10;36(2):210-216. doi: 10.1200/JCO.2017.74.9523. Epub 2017 Dec 8.
2
Integrated Molecular Characterization of Uterine Carcinosarcoma.子宫癌肉瘤的综合分子特征分析
Cancer Cell. 2017 Mar 13;31(3):411-423. doi: 10.1016/j.ccell.2017.02.010.
3
Mullerian carcinosarcoma arising from intestinal endometriosis.源于肠道子宫内膜异位症的苗勒管癌肉瘤
J Clin Oncol. 2013 Apr 10;31(11):e175-7. doi: 10.1200/JCO.2012.44.1600. Epub 2013 Mar 4.
4
Epithelial-mesenchymal transition in carcinomas of the female genital tract.女性生殖道癌中的上皮-间质转化。
Histopathology. 2013 Jan;62(1):31-43. doi: 10.1111/his.12057.
5
Epigenetic inactivation of hMLH1 in the malignant transformation of ovarian endometriosis.卵巢子宫内膜异位症恶变中 hMLH1 的表观遗传失活。
Arch Gynecol Obstet. 2012 Jan;285(1):215-21. doi: 10.1007/s00404-011-1922-x. Epub 2011 May 10.
6
The basics of epithelial-mesenchymal transition.上皮-间质转化的基础知识。
J Clin Invest. 2009 Jun;119(6):1420-8. doi: 10.1172/JCI39104.
7
Endometrioid endometrial adenocarcinoma recurring as carcinosarcoma.子宫内膜样腺癌复发为癌肉瘤。
J Obstet Gynaecol Res. 2008 Apr;34(2):279-82. doi: 10.1111/j.1447-0756.2008.00771.x.
8
Endometrial carcinoma recurring as carcinosarcoma: report of two cases.子宫内膜癌复发为癌肉瘤：两例报告。
Pathol Res Pract. 2007;203(9):677-81. doi: 10.1016/j.prp.2007.05.008. Epub 2007 Jul 23.
9
Retroperitoneal müllerian carcinosarcoma associated with endometriosis: a case report.与子宫内膜异位症相关的腹膜后苗勒管癌肉瘤：一例报告
Gynecol Oncol. 2004 May;93(2):546-9. doi: 10.1016/j.ygyno.2004.01.018.
10
Endometriosis-associated intestinal tumors: a clinical and pathological study of 6 cases with a review of the literature.子宫内膜异位症相关肠道肿瘤：6例临床病理研究并文献复习
Hum Pathol. 2000 Apr;31(4):456-63. doi: 10.1053/hp.2000.6712.