Aye Thandar, Arndt Patricia A
Senior Technologist, Immunohematology Reference Laboratory, Bloodworks NW.
Lead Technologist, Special Immunohematology Laboratory, American Red Cross Blood Services, Southern California Region.
Immunohematology. 2018 Sep;34(3):98-102.
Chloroquine diphosphate (CDP) is a helpful tool in the blood bank for two main applications. The most common application is to render direct antiglobulin test-positive red blood cells (RBCs) free from membrane-bound IgG; these treated RBCs can then be used for autologous adsorption and/or to determine the patient's RBC phenotype. Another common use of CDP is to remove human leukocyte antigens (HLAs) from RBCs to help identify or exclude the presence of antibodies to HLAs expressed on RBCs, for example, Bennett-Goodspeed (Bg) antigens. In this review, the principles, applications, and limitations of using CDP are discussed.
二磷酸氯喹（CDP）在血库中有两个主要用途，是一种很有用的工具。最常见的用途是使直接抗球蛋白试验阳性的红细胞（RBC）去除膜结合的免疫球蛋白G（IgG）；这些经过处理的红细胞随后可用于自体吸附和/或确定患者的红细胞表型。CDP的另一个常见用途是从红细胞中去除人类白细胞抗原（HLA），以帮助识别或排除针对红细胞上表达的HLA的抗体的存在，例如贝内特-古德斯皮德（Bg）抗原。在这篇综述中，将讨论使用CDP的原理、应用和局限性。
