IEEE Trans Med Imaging. 2019 Apr;38(4):894-908. doi: 10.1109/TMI.2018.2874545. Epub 2018 Oct 8.
Ultrasound shear wave elastography is an imaging modality for noninvasive evaluation of tissue mechanical properties. However, many current techniques overestimate lesions dimension or shape especially when small inclusions are taken into account. In this paper, we propose a new method called local phase velocity-based imaging (LPVI) as an alternative technique to measure tissue elasticity. Two separate acquisitions with ultrasound push beams focused once on the left side and once on the right side of the inclusion were generated. A local shear wave velocity is then recovered in the frequency domain (for a single frequency or frequency band) for both acquired data sets. Finally, a two-dimensional shear wave velocity map is reconstructed by combining maps from two separate acquisitions. Robust and accurate shear wave velocity maps are reconstructed using the proposed LPVI method in calibrated liver fibrosis tissue mimicking homogeneous phantoms, a calibrated elastography phantom with stepped cylinder inclusions and a homemade gelatin phantom with ex vivo porcine liver inclusion. Results are compared with an existing phase velocity-based imaging approach and a group velocity-based method considered as the state of the art. Results from the phantom study showed that increased frequency improved the shape of the reconstructed inclusions and contrast-to-noise ratio between the target and background.
超声剪切波弹性成像是一种用于无创评估组织力学特性的成像方式。然而,许多当前的技术方法在评估小的病灶时会高估病灶的尺寸或形状。在本文中,我们提出了一种称为基于局部相速度成像(LPVI)的新方法,作为一种替代技术来测量组织弹性。使用超声推束产生两次单独的采集,一次聚焦在病灶的左侧,一次聚焦在病灶的右侧。然后在两个采集数据集的频域中恢复局部剪切波速度(对于单个频率或频带)。最后,通过组合来自两次单独采集的图谱来重建二维剪切波速度图谱。使用所提出的 LPVI 方法在经过校准的肝纤维化组织模拟体模、具有阶梯圆柱病灶的校准弹性成像体模以及带有离体猪肝病灶的自制明胶体模中重建了稳健且精确的剪切波速度图谱。结果与现有的基于相速度成像方法和被认为是现有技术的基于群速度方法进行了比较。体模研究的结果表明,增加频率可以改善重建病灶的形状和目标与背景之间的对比度噪声比。