Kisvárday Z F, Adams C B, Smith A D
Neuroscience. 1986 Dec;19(4):1179-86. doi: 10.1016/0306-4522(86)90131-4.
The human temporal cortex contains a type of interneuron, identified by Golgi impregnation which, like the axo-axonic or chandelier cells found in animals, establishes Gray's type II synaptic contacts exclusively with the axon initial segments of pyramidal cells. Each terminal segment is composed of 3-12 boutons to form a "chandelier"-like appearance. For the two human axo-axonic cells analysed in this study we could identify 269 and 86 bouton rows respectively, which represents an equivalent number of postsynaptic pyramidal cells. A terminal bouton row from one of these Golgi-impregnated cells was shown to be in synaptic contact with the axon initial segment of a Golgi-impregnated pyramidal cell. The very specific nature of the target of axo-axonic cells, together with their highly divergent axonal arborization, means that they are ideally placed to control the output of a large population of pyramidal cells. Since previous studies in animals have shown the GABAergic nature of axo-axonic cells it is possible that human axo-axonic cells could be involved in the generation of epileptic activity or in the control of its propagation.
人类颞叶皮质包含一种中间神经元，通过高尔基染色法得以识别。这种神经元与在动物中发现的轴突 - 轴突型或吊灯样细胞类似，仅与锥体细胞的轴突起始段建立格雷氏II型突触联系。每个终末段由3 - 12个终扣组成，形成“吊灯”样外观。对于本研究中分析的两个人类轴突 - 轴突型细胞，我们分别可以识别出269排和86排终扣，这代表了同等数量的突触后锥体细胞。其中一个经高尔基染色的细胞的一排终末扣被证明与一个经高尔基染色的锥体细胞的轴突起始段存在突触联系。轴突 - 轴突型细胞靶标的高度特异性，连同其高度发散的轴突分支，意味着它们处于理想位置来控制大量锥体细胞的输出。由于先前对动物的研究表明轴突 - 轴突型细胞具有γ-氨基丁酸能性质，因此人类轴突 - 轴突型细胞有可能参与癫痫活动的产生或其传播的控制。
