Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China.
Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China.
Clin Chim Acta. 2018 Dec;487:233-240. doi: 10.1016/j.cca.2018.10.011. Epub 2018 Oct 5.
Apelin, an endogenous ligand for the G protein-coupled receptor APJ, is widely expressed in various organs. Recent research has indicated that the Apelin/APJ system plays an important role in aging. Apelin and APJ receptor expression are down-regulated with increasing age. In murine models, Apelin and APJ knockouts exhibit accelerated senescence whereas Apelin-restoration results in enhanced vigor and rejuvenated behavioral and circadian phenotypes. Furthermore, aged Apelin knockout mice develop progressive impairment of cardiac contractility associated with systolic dysfunction. Apelin is crucial to maintain cardiac contractility in aging. Moreover, the Apelin/APJ system appears to be involved in regulation of renin-angiotensin-aldosterone system (RAAS), apoptosis, inflammation and oxidative stress which promotes aging. Likewise, the Apelin/APJ system regulates autophagy, stem cells and the sirtuin family thus contributing to anti-aging. In this review, we describe the relationship between Apelin/APJ system and aging. We elaborate on the role of the Apelin/APJ system in aging stimulators, aging inhibitors and age-related diseases such as obesity, diabetes and cardiovascular disease. We conclude that Apelin/APJ system might become a novel promising therapeutic target for anti-aging.
Apelin 是 G 蛋白偶联受体 APJ 的内源性配体，广泛表达于各种器官。最近的研究表明 Apelin/APJ 系统在衰老中起着重要作用。Apelin 和 APJ 受体的表达随年龄的增长而下调。在小鼠模型中，Apelin 和 APJ 敲除会导致衰老加速，而 Apelin 恢复则会增强活力并恢复行为和昼夜节律表型。此外，衰老的 Apelin 敲除小鼠会出现与收缩功能障碍相关的进行性心肌收缩力下降。Apelin 对于维持衰老过程中心肌收缩力至关重要。此外，Apelin/APJ 系统似乎参与了肾素-血管紧张素-醛固酮系统 (RAAS)、细胞凋亡、炎症和氧化应激的调节，这些调节会促进衰老。同样，Apelin/APJ 系统调节自噬、干细胞和沉默信息调节因子家族，从而有助于抗衰老。在这篇综述中，我们描述了 Apelin/APJ 系统与衰老的关系。我们详细阐述了 Apelin/APJ 系统在衰老刺激物、衰老抑制剂以及肥胖症、糖尿病和心血管疾病等与年龄相关的疾病中的作用。我们得出结论，Apelin/APJ 系统可能成为抗衰老的一个新的有前途的治疗靶点。
