Institutes for Life Sciences, School of Medicine and National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guangdong 510006, China.
Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore.
J Control Release. 2018 Nov 28;290:129-137. doi: 10.1016/j.jconrel.2018.09.028. Epub 2018 Oct 5.
Fluorescent drug delivery systems provide a means to track drug release, trace processes of translocation, monitor excretion of anticancer agents and predict therapeutic responses. Traditional fluorescent dye-labeled drug delivery systems often suffer from notorious aggregation-caused quenching (ACQ) with greatly impeded imaging performance. The emerging fluorogens with aggregation-induced emission characteristics (AIEgens) have provided an elegant alternative to tackle this challenge. Recently, fluorescent drug delivery systems based on AIEgens which combine fluorescence imaging and drug delivery have been extensively studied for the development of theranostic nanomedicine. In this review, we summarize the recent development of fluorescent drug delivery systems using AIEgens as the signal reporter. This review is organized according to the drug delivery systems, which include: (1) AIEgens as the drug delivery carrier; (2) AIE polymer as the drug delivery carrier; (3) Organic-inorganic AIE nanocarrier for drug delivery; (4) Supramolecular AIE system for drug delivery. Through illustration of their design principles and application examples, we hope to stimulate more interest in the design of more advanced fluorescent drug delivery systems based on AIEgens for cancer therapy.
荧光药物传递系统提供了一种追踪药物释放、跟踪转位过程、监测抗癌药物排泄和预测治疗反应的方法。传统的荧光染料标记药物传递系统常常受到严重的聚集诱导猝灭（ACQ）的困扰，极大地阻碍了成像性能。具有聚集诱导发射特性（AIEgen）的新兴荧光团为解决这一挑战提供了一种优雅的替代方案。最近，基于 AIEgen 的荧光药物传递系统作为荧光成像和药物传递的结合体，已经被广泛研究用于开发治疗诊断纳米医学。在这篇综述中，我们总结了最近使用 AIEgen 作为信号报告器的荧光药物传递系统的发展。本综述根据药物传递系统进行组织，包括：（1）AIEgen 作为药物传递载体；（2）AIE 聚合物作为药物传递载体；（3）用于药物传递的有机-无机 AIE 纳米载体；（4）用于药物传递的超分子 AIE 体系。通过说明它们的设计原则和应用实例，我们希望激发更多兴趣，设计出更先进的基于 AIEgen 的荧光药物传递系统，用于癌症治疗。
