进食障碍中体外细胞因子产生的系统评价。
A systematic review of in vitro cytokine production in eating disorders.
机构信息
Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Faculty of Life Sciences and Medicine, King's College London, UK.
出版信息
Mol Cell Endocrinol. 2019 Nov 1;497:110308. doi: 10.1016/j.mce.2018.10.006. Epub 2018 Oct 6.
BACKGROUND
Eating disorders (EDs) have been associated with alterations in cytokine concentrations and production. This review examines whether in vitro cytokine production (i) is altered in people with EDs compared to healthy participants; and (ii) changes in response to treatment?
METHODS
Using PRISMA guidelines, we systematically reviewed articles reporting group comparisons or longitudinal assessments of spontaneous and/or stimulated cytokine production in vitro in people with EDs.
RESULTS
Twelve studies were included. Cross-sectional results were mixed in anorexia nervosa. Only one study measured cytokine production in bulimia nervosa. Two longitudinal studies showed that daily yoghurt consumption increases phytohemagglutinin-stimulated interferon-γ production in anorexia nervosa.
CONCLUSION
The mixed results could be accounted for by variations in experimental design. Our findings suggest that cytokine production could possibly be modulated through dietary interventions. However, due to the methodological heterogeneity and shortcomings of the included studies, it seems unreasonable to draw further conclusions.
背景
饮食失调（EDs）与细胞因子浓度和产生的改变有关。本综述探讨了体外细胞因子产生（i）是否在 ED 患者与健康参与者相比发生改变；以及（ii）是否会对治疗产生变化？
方法
我们使用 PRISMA 指南，系统地回顾了报告 ED 患者体外细胞因子自发和/或刺激产生的组间比较或纵向评估的文章。
结果
纳入了 12 项研究。厌食症的横断面结果不一致。只有一项研究测量了神经性贪食症中的细胞因子产生。两项纵向研究表明，每天食用酸奶可增加厌食症患者植物血凝素刺激的干扰素-γ产生。
结论
混合的结果可以归因于实验设计的变化。我们的研究结果表明，细胞因子的产生可能通过饮食干预来调节。然而，由于纳入研究的方法学异质性和缺点，进一步得出结论似乎不合理。
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